Striatal sections immunofluorescence and analysis
Output Details
Description
Previous studies have shown that the phosphorylation of ribosomal protein S6 (p-rpS6) at S235/236 residues increases in iSPNs in response to haloperidol activation. This phosphorylation is cAMP/PKA dependent, which is the canonical pathway inhibited by D2R antagonism. We therefore explored whether LRRK2 inhibition interferes with this haloperidol-mediated phosphorylation event.
Identifier (DOI)
10.17504/protocols.io.n2bvjnpmxgk5/v1
