suny-downstate-medical-center/pd_m1_6ohda: M1_Control_6OHDA
By onLiqiang Chu et al found decreased excitability in these neurons in a Parkinson's mouse model. A simulation using NetPyNE was created to study the impact of the changed PT5B neuron on motor cortex spiking dynamics.
Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons
By onProtocol for depleting or tagging endogenous α-syn using virally-delivered CRISPR-Cas9 in hippocampal neurons
Zhai et al. 2025 Raw data
By onData includes immunohistochemistry images, two-photon images of patched neurons, whole-cell recordings for somatic excitability and Sr2+-oEPSC, spine density imaging, ACh sensor imaging, and dendritic excitability linescan data.
Integrated Representations of Threat and Controllability in the Lateral Frontal Pole
By onEmotions can strongly influence behavior, as seen in PD paradoxical kinesia. Here, we demonstrate that anticipating threats enhances motor accuracy through interactions between the amygdala and the anterior pole of the lateral prefrontal cortex.
FSCV dopamine, spike, and LFP data used for validating chronic electrode implanted in aseptic semi-sealed chamber
By onFSCV dopamine, spike, and LFP data used for validating chronic electrode implanted in aseptic semi-sealed chamber in Choi et al. 2025 JNeurosciMethods.
Choice Reaction Time Reaching Task for Non-human Primate
By onThis protocol describes the behavioral task used with both healthy and MPTP-induced hemiparkinsonian non-human primates in the Turner Lab at the University of Pittsburgh, as well as the training procedure for introducing the task to naïve NHPs.
MatLab Code and Source Data for Analyzing Reach-related Single Unit Activity in the Internal Segment of the Globus Pallidus in Parkinsonian Macaque
By onSource data stored in a non-proprietary format, all MATLAB code, along with histology data prepared for the publication of our study on movement-related activity in the internal globus pallidus of parkinsonian macaques (Kase et al. 2025).
