Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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Theme
Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
This study used neuroimaging to show a ventral putamen-centered open-loop circuit linking emotions and movement in humans. Contextual incentives influence which motor circuit is activated, shedding light on paradoxical kinesia in Parkinson's Disease.
Extracellular space diffusion modelling identifies distinct functional advantages of archetypical glutamatergic and GABAergic synapse geometries
We modelled extracellular diffusion in super-resolved images of live brain tissue neuropil. We found that extracellular space geometry shapes local diffusion and this has functional implications for signaling arising from synaptic spill-over.
Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
This methods paper outlines silencing transposable elements in hiPSCs using CRISPRi. Describes gRNA design, validation via multiome approach. Enables functional studies on TE transcription in hiPSC models.
Single cell eQTL mapping reveals convergent glial–neuronal risk architecture in Parkinson’s disease
Population-scale, disease-context aware meta single-nucleus eQTLs mapping (N = 1,197) in nine cell types from cortex and substantia nigra identifies 125 risk genes and cell types for PD GWAS signals.
Striatal dopamine signals internal states related to behavioral performance over prolonged timescales in monkeys
Dopamine plays dual roles in behavior: fast reward prediction errors and slow motivational states. Dopamine release in monkeys' brain regions tracks performance changes, suggesting a single signal for both functions.
FISH CODETECTION
DIG and Fluorescein labeled riboprobes Fluorescent in situ hybridization Frozen brain sections
An ImageJ/FIJI Preprocessing Workflow for Multi-Series Confocal Microscopy Datasets Prior To CellProfiler Analysis
A workflow using ImageJ/FIJI aims to create three-slice MIPs from multi-series .czi files to capture weak signals. It involves extracting datasets, creating projections, and saving images for efficient analysis in CellProfiler.
Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster
In 933 PD cases vs 291 controls, mood/sleep disorders (depression, anxiety, apnea, RLS) were more common and clustered. Pesticides and head trauma raised odds; smoking lowered. 43% of PD had a mood/sleep disorder.
Methods for “Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model”
Collection of protocols used for the manuscript entitled "Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model".
Raw datasets for “Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model”
This dataset contains all primary data and quantifications
Datasets for Murray et al. 2026 (Prolonged Timescales) Manuscript
Trial information, dopamine data, and autonomic/behavioral data used for the prolonged timescales Murray et al. 2026 manuscript
Code for Murray et al. 2026 (Prolonged Timescales) Manuscript
Source code to replicate core analyses used throughout the Murray et al. 2026 (Prolonged Timescales) manuscript.
Neural Control of Autonomic Arousal During Threat Anticipation Revealed by High-Resolution Cardiac Contractility
These findings highlight neural correlates of adaptive behavioral mobilization during emotion-guided action, shedding light on motor circuitry that may be engaged during paradoxical kinesia, a phenomenon of emotion-relevant motor facilitation in PD.
Data and code for Stasiak et al. 2026 (TREV-Emotion) Manuscript
Online repository for the data and scripts used in the Stasiak et al., 2026 preprint on TREV-derived cardiac contractility in threat anticipation contexts.
Protocol for Stasiak et al. 2026 (TREV-Emotion) Manuscript
Protocol for Stasiak et al. 2026 (TREV-Emotion) Manuscript. Describes participant preparation, shock calibration, scan sequence, active escape task, and participant debriefing.
