Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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An open-source head-fixation and implant-protection system for mice
This study presents a head-fixation and implant-protection system for mice including a headbar, headhat and head fixation station to facilitate experimental procedures in vivo. All 3D-printing files are open source and readily available and editable
Astrocytic LRRK2 Controls Synaptic Connectivity through ERM Phosphorylation
This study shows that the Lrrk2 gene affects astrocyte morphology by regulating ERM protein phosphorylation, which when reduced, restores synaptic function in PD, suggesting astrocytes as potential therapeutic targets.
Reward perseveration is shaped by GABAA-mediated dopamine pauses
This study employs a novel drug targeting technology DART(drug acutely restricted by tethering), to selectively block GABAA receptors on VTADA neurons as mice engage in Pavlovian learning.
The integrated stress response in brain diseases: A double-edged sword for proteostasis and synapses
This review article discusses the role of ISR on the synaptic plasticity in brain disorders as well as its potential as a therapeutic target to improve circuit function
SynBot is an open-source image analysis software for automated quantification of synapses
Synapses are crucial for brain function. SynBot, an open-source software, automates synapse analysis using advanced algorithms to improve accuracy and reproducibility in studying synaptic phenotypes
Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology
This review article focuses on the key biological features of DAergic neurons that increase neurotoxicant susceptibility
GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes
GEARBOCS is a non-invasive method for precise gene editing in astrocytes using CRISPR/Cas9. It allows knockout, tagging, and reporter knock-in strategies, revealing the roles of Sparcl1 and Vamp2 in synapse maintenance in the mouse visual cortex.
DIO-SPOTlight Transgenic Mouse to Functionally Monitor Protein Synthesis Regulated by the Integrated Stress Response
A new SPOTlight reporter allows visualization of the integrated stress response (ISR) activity in specific cell types in transgenic mice, aiding in studying health and disease implications.
Assembloid model to study loop circuits of the human nervous system
Human stem cells are used to create in vitro cortico-striatal-thalamic-cortical circuits, mimicking neural networks involved in neuropsychiatric disorders. This system allows study of normal development and diseases like autism and Tourette syndrome.
Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex
Mitochondrial fission in astrocytes plays a key role in brain development. Loss of Drp1 disrupts mitochondrial distribution, leading to astrocyte morphological changes and organization disruptions, impacting neurodevelopment and Connexin 43 levels.
Astrocytic polyamine transport by ATP13A4 tunes excitatory synaptic transmission
Polyamines are crucial for brain function. ATP13A4 is the main polyamine transporter in astrocytes, impacting astrocyte morphology, synapse formation, and neurodevelopment. Mutations in ATP13A4 are linked to neurodevelopmental disorders.
