Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Adenosine in the brain: recent progress on detection, function and translation
Recent advancements have expanded our understanding of adenosine in the brain, revealing its role in regulating brain circuits for sleep, movement, cognition, and more.
A molecular atlas of cell-type specific signatures in the parkinsonian striatum
Progressive dopamine loss in PD affects striatum cells differently. Transcriptomic analysis in mouse and human models reveals changes in neuronal and glial populations, highlighting resilient and vulnerable cell types for potential new treatments.
Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation
The results highlight the unique utility of modeling striatal neurons in a modular and highly physiological circuit, which is essential to reveal mechanistic insights of the loss of electrical functional integrity in the striata of GBA1 PD patients.
Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson’s
This data show that LTCC function in DA axons, and isradipine effect, are locally governed and suggest they vary in a manner that in turn might impact on, or reflect, the cellular stress that leads to parkinsonian degeneration.
Impaired dopamine release in Parkinson’s disease
Evidence indicates that impaired dopamine release can result from disruption to a diverse range of Parkinson’s disease-associated genetic and molecular disturbances and can be considered a potential pathophysiological hallmark of Parkinson’s…
Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers
The secretion of endogenous α-syn mediated by DNAJC5 is found in a human neuroblastoma cell line, The authors propose that DNAJC5 forms a palmitoylated oligomer to accommodate and export α-syn.
Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility
Here, the authors propose that GPi Sst+ neurons drive behavioral flexibility through a direct feedback signal to balance the activity of key nodes in the basal ganglia.
Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease
This study used two complementary approaches in a Parkinson's disease mouse model and revealed insights into dopaminergic neuron characteristics, aging markers, and potential disease genes like CASR.
A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy
The authors built a microfluidic device that mimics neuronal circuits and enables drug screening for effects on neuronal connections.
Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior
The authors designed a new micro-fiber array approach capable of chronically measuring and optogenetically manipulating local dynamics across over 100 targeted locations simultaneously in head-fixed and freely moving mice.
Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes
The authors found very rapid modulation of dopamine release at sub-second timescales, mediated by changes to acetylcholine signalling, and a surprising cell-to-cell “satellite” configuration of astrocytes next to striatal cholinergic…
An axonal brake on striatal dopamine output by cholinergic interneurons
Depolarization of axons is crucial for triggering neurotransmitter release. Cholinergic interneurons and nicotinic receptors in the striatum interrupt this process, causing a temporary suppression of dopamine release.
Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations
Striatal acetylcholine (ACh) signaling in mice shows opposing changes across different regions, with positive and negative prediction errors encoded in anterior dorsal striatum.
Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson’s disease bradykinesia and procedural motor learning impairment
Vulnerable Anxa1-expressing DANs are reduced in prodromal PD, affecting movement and procedural learning. Their dysfunction explains early PD symptoms like bradykinesia and motor impairments.
