Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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Program
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CRN Team Name
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Theme
Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy
Parkinson’s disease (PD) involves motor symptoms and αsyn aggregation. GBA1 mutations may worsen PD progression. Testing showed similar αsyn spread regardless of genotype or αsyn strain, with unique interactions found in GBA-PD brains.
Alpha-synuclein aggregates are phosphatase resistant
CIAP pretreatment has important implications for the mechanism of PSER129-accumulation in the synucleinopathy brain and provides a simple experimental method to differentiate endogenous from aggregated PSER129.
Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease
Study focuses on mild motor deficits not meeting Parkinson's criteria. Nigrostriatal system changes occur regardless of alpha-synuclein presence, hinting at tau-mediated dopaminergic neurodegeneration initiation. Tau pathology seen in affected groups
