Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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A Multimodal Atlas Reveals the Anatomical Distribution of Medium Spiny Neuron Subtypes and a Novel RGS6+ Population in the Primate Striatum
We combined single-nucleus multi-omic sequencing and high-plex spatial transcriptomics to build a comprehensive atlas of medium spiny neurons (MSNs) across the entire macaque striatum, revealing new MSN subtypes and their association with diseases.
Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents
The authors' CFET array has the potential to unlock a wide range of applications, from uncovering the role of neuromodulators in synaptic plasticity, to addressing safety barriers in clinical translation toward diagnostic and adaptive treatment in PD
Detecting rhythmic spiking through the power spectra of point process model residuals
The work highlighted in this manuscript improves the ability to characterize oscillatory activity and detect pathological changes at the level of individual neurons.
Synchronous Measurements of Extracellular Action Potentials and Neurochemical Activity with Carbon Fiber Electrodes in Nonhuman Primates
The authors developed methods for synchronous measures of neuron spikes and dopamine signals in the monkey striatum. These methods will help advance our understanding of the interactions between neuromodulator signaling and neuronal activity.
An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkey
The authors developed an MRI-compatible stereotaxic frame for use in various nonhuman primate species to allow precise multimodal alignment without marker implantation. The design files are publicly available to facilitate low-cost manufacturing.
Dysfunction of Motor Cortices in Parkinson’s disease
In this review, the authors discuss PD-related changes in frontal cortical motor regions, focusing on neuropathology, changes in neurotransmission, and altered network interactions.
Dissociation of novel open loop from ventral putamen to motor areas from classic closed loop in humans II: task-based function
Humans increase the speed of their movements when motivated by incentives. The authors analyzed the profile of two circuits involving putamen and motor cortical areas to assess the interplay between incentivization and motor output.
A neurocomputational view of the effects of Parkinson’s disease on speech production
This article reviews the role of cortico-basal ganglia circuits in speech motor learning and execution in Parkinson's disease.
Dissociation of putative open loop circuit from ventral putamen to motor cortical areas in humans I: high-resolution connectomics
High-resolution connectomics in human participants provides evidence for a non-canonical circuit linking the limbic ventral putamen to the motor cortex. These data are in line with previous findings in nonhuman primates.
Movement-related activity in the internal globus pallidus of the parkinsonian macaque
This study of MPTP-induced parkinsonism in macaques indicates that changes in the timing of task-related neural activity of the internal segment of the globus pallidus (GPi) correlate with the severity of motor impairments.
Microinvasive Probes for Monitoring Electrical and Chemical Neural Activity in Nonhuman Primates
We designed carbon fiber sensors that enable long-term simultaneous recording of both neurochemical and electrical neural activity in deep brain structures of nonhuman primates.
Aseptic, semi-sealed cranial chamber implants for chronic multi-channel neurochemical and electrophysiological neural recording in nonhuman primates
We developed an implantable neural interface in monkeys that allows dual monitoring of electrical and chemical neural activity for long-term studies.
Integrated Representations of Threat and Controllability in the Lateral Frontal Pole
Emotions can strongly influence behavior, as seen in PD paradoxical kinesia. Here, we demonstrate that anticipating threats enhances motor accuracy through interactions between the amygdala and the anterior pole of the lateral prefrontal cortex.
