Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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Multiscale model of primary motor cortex circuits predicts in vivo cell type-specific, behavioral state-dependent dynamics
A detailed multiscale model of mouse primary motor cortex accurately predicted responses to behavioral states and manipulations, aiding in understanding cortical function at different scales.
Simulations predict differing phase responses to excitation vs. inhibition intheta-resonant pyramidal neurons
This research highlights how cortical neurons respond differently to oscillatory inputs, impacting neuronal responses to network state shifts.
Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE
The work provides a widely accessible, data-driven and biophysically-detailed model of the somatosensory thalamocortical circuits that can be utilized as a community tool for researchers to study neural dynamics, function and disease.
Synaptic Location Is a Determinant of the Detrimental Effects of α-Synuclein Pathology to Glutamatergic Transmission in the Basolateral Amygdala
Study explores α-synuclein's impact on amygdala in Parkinson's. Aggregation affects cortico-BLA transmission, linked to psychiatric deficits in PD.
Reduced Thalamic Excitation to Motor Cortical Pyramidal Tract Neurons in Parkinsonism
The current data suggests that cell subtype- and synapse-specific adaptations in M1 contribute to altered cortical outputs in parkinsonism and are important aspects of PD pat
Basal ganglia neurons in healthy and parkinsonian primates generate recurring sequences of spikes
Basal ganglia neurons fire in recognizable, repeating sequences of interspike intervals (ISIs), the incidence of which is influenced by the induction of Parkinsonism.
Open-Source Platform for Kinematic Analysis of Mouse Forelimb Movement
An open-source behavioral platform and software solution for studying fine motor skills in mice performing reach-to-grasp tasks.
Dysfunction of Motor Cortices in Parkinson’s disease
In this review, the authors discuss PD-related changes in frontal cortical motor regions, focusing on neuropathology, changes in neurotransmission, and altered network interactions.
Enhanced beta power emerges from simulated parkinsonian primary motor cortex
M1 layer 5B pyramidal tract neurons show intrinsic pathology in Parkinson's disease models. Computer simulations reveal decreased excitability alters M1 network activity, increasing beta band power, a hallmark of PD.
Microendoscopic calcium imaging in motor cortices of macaques during rest and movement
Motor cortical regions have undergone evolutionary expansion and specialization from rodents to primates. Studying these regions in non-human primates (NHPs) is relevant to understanding motor control in NHP models of movement disorders.
Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation
Our results documented motor cortical neuronal hyperexcitability associated with αSyn aggregation and provided a novel mechanistic understanding of cortical circuit dysfunction in PD
α-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice
The study suggests that early circuit modulation could be an effective approach to alleviate symptoms associated with α-Syn pathology, necessitating studies of functional consequences of α-Syn aggregation.
Motor cortical circuit adaptations in parkinsonism
Perspective article on the publication (Chen et al. (2023), Sci Adv). It summarizes the major findings of this research paper and highlights a few potential future directions regarding the motor cortical circuit changes in parkinsonism.
Progressive noradrenergic degeneration and motor cortical dysfunction in Parkinson’s disease
The article discusses clinical and preclinical studies that support the critical rolLC-NE neurodegeneration and motor cortical dysfunction in both motor and nonmotor deficits in Parkinsonian states.
Subsecond Analysis of Locomotor Activity in Parkinsonian Mice
This work documents robust changes in the velocity, usage, and temporal organization of behavioral modules, as well as their responsiveness to dopaminergic treatment under the Parkinsonian state.
