Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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Dataset for “A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss”
Immune system activation may contribute to PD development. Infection increases BBB permeability in mice, leading to brain inflammation. This suggests infections could trigger PD in genetically susceptible individuals.
Dataset for “STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation”
STING pathway activation impacts antigen presentation through the UPR and may be a target for therapeutic intervention in PD and autoimmune diseases.
Dataset for “An LRRK2 variant blocks NCOA4 trafficking upon iron overload, leading to ferroptotic death”
LRRK2 as a key regulator of iron homeostasis and point to the need for an increased focus on the mechanisms of iron dysregulation in PD
Proteomics for “An LRRK2 variant blocks NCOA4 trafficking upon iron overload, leading to ferroptotic death”
LRRK2 as a key regulator of iron homeostasis and point to the need for an increased focus on the mechanisms of iron dysregulation in PD
Dataset for Article “Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum”
This is the primary dataset for the article by Miller-Hansen et al "Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum"
Datasets for Belal et al. ‘Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models’
Deposit contains processed data spreadsheets and SVG figure panels generated from the raw electrophysiology, imaging and in-situ hybridization recordings.
Flow cytometry data from the manuscript “Fluorescence-Gated Flow Cytometry Approach for Measuring Lipid Flippase Activity in Mamma-lian Cells”
Summary: The manuscript presents a fluorescence-gated flow cytometry method to measure lipid flippase activity in mammalian cells.
Image resources (Garza et al. 2026)
Brightfield, Immunofluorescent images of KOLF2.1-derived microglia (MGlia) and RC17 hES cells derived dopaminergic neurons by Garza et al (2026).
iPSC QC (Garza et al, 2026)
Quality control reporting table and imaging files for hiPSCs and hESCs lines used in Garza et al., 2026.
Dandiet: Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in Substanta nigra
This is a Dandiet that hosts binary files of electrophysiology data for the titled manuscipt 'Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in Substanta nigra'.
Fushiki et al – Video Recording of Parkinson’s Disease Model Mice
Raw behavioral datasets and experimental video recordings referenced in the paper( https://www.biorxiv.org/content/10.1101/2024.12.20.629776v1).
Imaging Dataset for: A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease
Dataset includes imaging data from experiments detailed in PMID: 39763754. Coronal brain sections imaged with fluorescence microscopy to assess reporter and transgene expression.
Histology from Rodrigues-Vaz and Athalye et al: Imaging of specific mouse brain region where viral injection and implant was placed at
This dataset is part of an experiment in which dorsolateral striatum (DLS) was imaged while mice performed task. This images show targeting of viral expression and lens implant to DLS.
2-photon imaging raw data from striatal populations through GRIN lens
The neuronal activity of striatal cells was acquired while the mouse performed a two-action isometric forelimb force task.
Holographic stimulation of neuronal ensembles in striatum
This dataset includes all the raw data regarding the experiments with 2-photon imaging, isometric force task and holographic stimulation in Rodrigues-Vaz & Athalye et al.
