Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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Program
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CRN Team Name
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Theme
Tansey Stool Meso Scale Discovery
Stool samples of healthy controls and individuals with either PD or IBD analyzed for chemokines, cytokines, and ferritin levels using U-PLEX and R-PLEX assays on Quickplex MSD instrument.
Bolen Human Sigmoid Colon Protein CosMx Datasets
Protein dataset from NanoString CosMx includes sigmoid colon samples from healthy controls, Parkinson's disease, and inflammatory bowel disease patients for analysis.
Tansey Plasma Meso Scale Discovery
Plasma samples from individuals with Parkinson's disease, inflammatory bowel disease, or healthy controls were analyzed to measure chemokines and cytokines. The study used Quickplex MSD instrument following manufacturer's protocol.
Bolen Human Sigmoid Colon RNA CosMx Dataset
NanoString CosMx RNA dataset from human sigmoid colon of healthy controls, Parkinson's Disease, or inflammatory bowel disease exported for analysis.
Generation of knock-in Cre and FlpO mouse lines for basal ganglia and dopamine neuron investigation (SOURCE DATA)
The dataset contained in this repository are the processed data and information used in all the quantifications, tables, and figures associated with the project by Albarran et al 2025 elife.
Albarran et al Histology dataset
Dataset from a whole-brain imaging experiment showing recombinase expression in different brain regions using knock-in lines (D1-Cre, A2a-Cre, D1-FlpO, A2a-FlpO, DAT-FlpO) crossed with fluorescent reporter lines.
Single particle analysis datasets of in vitro grown aSyn filaments
Dataset includes cryo-EM micrographs of a-Synuclein fibrils with WT and mutant forms (G14R, K58N) found in patients.
Tomogram of aggregate in AgDD-sfGFP-expressing HEK293 cell 10 min post aggregation induction
AgDD protein aggregation can be controlled for cellular studies. A cryo-electron tomogram shows an AgDD aggregate in a HEK293 cell 10 min post-aggregation induction.
Tomogram of aggregate in AgDD-sfGFP-expressing HEK293 cell 6 h post aggregation induction
AgDD protein aggregation in HEK293 cells can be temporally controlled for studying cellular effects. A cryo-electron tomogram shows AgDD aggregate formation 6h post-induction.
Cryo-EM map of in vitro grown G14R alpha-synuclein fibrils
3.0 A resolution cryo-EM map obtained from recombinant a-synuclein fibrils carrying the G14R mutation recently discovered in a patient of a complex neurological disease.
Cryo-EM map of in vitro grown WT alpha-synuclein fibrils
Cryo-EM density map of recombinant WT a-synuclein fibrils at 2.7 A resolution.
Cryo-EM map of recombinant K58N alpha-synuclein fibrils
Cryo-EM map obtained from recombinant a-synuclein fibrils carrying the K58N mutation recently discovered in a patient of Parkinson's disease.
3d Structure of the Human Hippocampus by holo-tomography: Alzheimer Disease vs Control
Dataset from ESRF's ID16A beamline includes high-res X-ray nano-tomography data of human brain samples with Alzheimer’s, Parkinson’s, and control cases, along with acquisition details for reuse.
Replication Data for: 3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale X-ray phase-contrast tomography
Dataset from DESY, GINX Beamline, Germany offers X-ray phase-contrast tomography volumes of human brain tissue for 3D analysis and reproducible imaging workflow correlation with histological sections.
Metagenomics sequencing data of publication doi.org/10.3389/fnins.2025.1546203
The study explores the connection between *GBA1* gene variants and gut microbiome in a mouse model, shedding light on Parkinson's disease development.
