Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
-
Output Type
-
Program
-
CRN Team Name
-
Theme
Pseudogenes limit the identification of novel common transcripts generated by their parent genes
Genomic sequences with high sequence similarity cause short sequencing reads to align to multiple locations, thus complicating genomic analyses. The authors investigated the impact of pseudogenes on transcriptomic analyses.
ASAP CRN Cloud Release Notes – Version 3.0.0
Summary: Release notes for version 3.0.0 of CRN Cloud platform, released on September 30, 2025, detailing latest updates and enhancements.
ICC confocal images: Protein aggregation and calcium dysregulation are the earliest hallmarks of familial Parkinson’s disease in human midbrain dopaminergic neurons
Using hiPSCs, researchers identified early pathophysiological events, including oligomeric aggregate formation, impaired calcium signaling, and mitochondrial dysfunction, ultimately resulting in abnormal neuronal activity and cell death in PD.
Direct visualisation of alpha-synuclein oligomers in human brain tissue – Raw Data
Raw data showing direct visualisation of alpha-synuclein oligomers in human brain tissue.
Direct visualisation of alpha-synuclein oligomers in human brain tissue – Processed Data
Direct visualisation of alpha-synuclein oligomers in human brain tissue - Processed Data
RASP: A new method for single puncta detection in complex cellular backgrounds_data
RASP: A new method for single puncta detection in complex cellular backgrounds_data.
RASP: A new method for single puncta detection in complex cellular backgrounds
RASP, a bioimaging-segmentation method, excels in detecting fluorescent puncta in complex biological systems by removing false positives and detecting features at various spatial scales.
Targeted long-read RNA-seq
Targeted long-read RNAseq of SNCA, GBA1, and GBAP1. Three datasets are available: (i) human brain (ii) iPSC-derived astrocytes microglia neurons and (iii) iPSC-derived midbrain dopaminergic neurons.
Polarisation camera dSTORM datasets of actin in fixed HeLa cells labeled with phalloidin-Alexa Fluor 647
Polarisation camera dSTORM dataset of the actin of fixed HeLa cells labeled with phalloidin-Alexa Fluor 647.
Pixel-dependent offset, gain, variance and readnoise maps for CS505MUP polarisation camera
Four tif files are the pixel-dependent camera offset (in ADU counts), gain (in ADU counts/photoelectron), variance (in ADU counts^2) and readout noise (in photoelectrons) for the full sensor of a polarization camera (CS505MUP, Thorlabs)
Polarisation camera PAINT movie of single Nile red dyes binding to lipid bilayer-coated silica microspheres
This PAINT dataset is a movie of the fluorescence of single Nile red molecules reversibly binding to a lipid bilayer (DPPC + 40% cholesterol) on a 5 μm diameter silica microsphere (44054-5ML-F, Sigma-Aldrich).
Polarisation camera dSTORM datasets of actin in fixed HeLa cells labeled with phalloidin-Alexa Fluor 488
Polarisation camera dSTORM dataset of the actin of fixed HeLa cells labeled with phalloidin-Alexa Fluor 488.
Polarisation camera movies of T cells on a cover glass
Polarisation camera movies of T cells on a cover glass
Polarisation camera movie of single SYTOX Orange molecules on a cover glass
This image dataset is a movie of the fluorescence of single SYTOX Orange molecules (S34861, Invitrogen) dispersed on a cover glass.
Video S1 SYTOX Orange
Supporting movie showing single SYTOX Orange molecules dispersed on a cover glass
