Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Single cell transcriptomics from DAT-Cre mouse gut tissue
Colonic myenteric cells were dissociated, and live tdTomato-positive cells were FACS-collected. Colons were isolated from 2 male and female wild type adult DAT-Cre mice. Wild type C57Bl6/J was used as control for gating. Cells were processed…
Raw tabular data of confocal microscopic images for “Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content”
Using immunofluorescence we uncovered a subpopulation of tdTomato-immunoreactive neurons in the ENS exhibit dual-transmitter content (DAT/ChAT, DAT,nNOS)
Transcriptomic analysis of colonic lamina propria cells in PINK1 KO mice compared to wild type following intestinal microbial infection
Transcriptomic analysis of colonic lamina propria cells in PINK1 KO mice compared to wild type following intestinal microbial infection
Supporting data for “PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection”
Data associated with “PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection”
Transcriptomic analysis of colonic lamina propria cells in LRRK2 G2019S mice compared to wild type following intestinal microbial infection
Using scRNAseq and flow cytometry, we demonstrated that the Lrrk2 G2019S mutation is associated with an increased neutrophil presence in the colonic lamina propria during infection and a Th17 skewing, upregulated Il17a, and greater colonic…
Proteomics for STING KO and STINGRRAA RAW 264.7 macrophages
Using immunopeptidomics analysis we showed that STING regulates the repertoire of peptides displayed at the cell surface of macrophages during inflammation, highlighting a potential role in immunosurveillance and potential targets for therapy
Transcriptomics of primary bone marrow-derived macrophages from MAPL KO and control mice.
This work establishes a mitochondrial–lysosomal signaling axis in which MAPL-driven mtDNA export and gasdermin-mediated lysosomal permeabilization convert organelle stress into pyroptotic cell death.
