Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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Single particle analysis datasets of in vitro grown aSyn filaments
Dataset includes cryo-EM micrographs of a-Synuclein fibrils with WT and mutant forms (G14R, K58N) found in patients.
Tomogram of aggregate in AgDD-sfGFP-expressing HEK293 cell 10 min post aggregation induction
AgDD protein aggregation can be controlled for cellular studies. A cryo-electron tomogram shows an AgDD aggregate in a HEK293 cell 10 min post-aggregation induction.
Tomogram of aggregate in AgDD-sfGFP-expressing HEK293 cell 6 h post aggregation induction
AgDD protein aggregation in HEK293 cells can be temporally controlled for studying cellular effects. A cryo-electron tomogram shows AgDD aggregate formation 6h post-induction.
Cryo-EM map of in vitro grown G14R alpha-synuclein fibrils
3.0 A resolution cryo-EM map obtained from recombinant a-synuclein fibrils carrying the G14R mutation recently discovered in a patient of a complex neurological disease.
Cryo-EM map of in vitro grown WT alpha-synuclein fibrils
Cryo-EM density map of recombinant WT a-synuclein fibrils at 2.7 A resolution.
Cryo-EM map of recombinant K58N alpha-synuclein fibrils
Cryo-EM map obtained from recombinant a-synuclein fibrils carrying the K58N mutation recently discovered in a patient of Parkinson's disease.
Proteomic analysis of iNeurons lacking ER-phagy receptors
Proteomic analysis of iNeurons and cells lacking ER-phagy receptors FAM134C, FAM134A, FAM134B, TEX264, and CCPG1 showed distinct protein profiles, highlighting their roles in ER-phagy pathways.
Kgg proteomic data from mouse cortical neurons
Kgg proteomic data from mouse cortical neurons
Tomogram data of TauRD-Y forms amyloid-like aggregates in cells
Tomograms: The tomograms shown in Fig. 1d and Fig. 3c are available in the EMDB https://www.ebi.ac.uk/emdb/ through the following information: EMD ID: EMD-13739 (Fig. 1d) and EMD-13740 (Fig. 3c)
Proteomics of iNeurons or HeLa cells with or without FBXO7
TMT proteomics datasets from FBXO7-/- hESC differentiation to iNeurons and HeLa cells.
Raw tomogram of GFP-a-synuclein inclusion in primary mouse neuron expressing GFP-a-synuclein, seeded with PFFs
Raw data associated with DOI: 10.1038/s41467-021-22108-0
Raw tomogram of GFP-a-synuclein inclusion in primary mouse neuron expressing GFP-a-synuclein, seeded with MSA aggregates
Raw data associated with DOI: 10.1038/s41467-021-22108-0
APEX-autophagy cargo receptor proteomics with and without lysosomal damage
Proteomics data associated with DOI: 10.7554/eLife.72328
fcs files to “The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model”
Dataset associated with DOI: 10.17617/3.51VXU0
