Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Metagenomics sequencing data of publication doi.org/10.3389/fnins.2025.1546203
The study explores the connection between *GBA1* gene variants and gut microbiome in a mouse model, shedding light on Parkinson's disease development.
MSP abundance table associated with doi.org/10.3389/fnins.2025.1546203
Summary: The table displays the abundance of microbial species in the gut of GBA1 L444P/WT mouse model, exploring the connection between GBA1 host genotype and gut microbiome in Parkinson's disease research.
Read Alignment table associated with doi.org/10.3389/fnins.2025.1546203
Summary: The publication explores the link between the *GBA1* host genotype and gut microbiome in the *GBA1*L444P/WT mouse model, shedding light on Parkinson's disease development.
Clinical data associated with doi.org/10.1038/s41531-025-01063-3
Study shows severe *GBA1* variants contribute to Parkinson's Disease phenotype, impacting counseling and clinical trials. Findings available at doi.org/10.1038/s41531-025-01063-3.
Glucocerebrosidase, a Parkinson´s disease-associated protein, is imported into mitochondria and regulates complex I assembly and function
Raw data files used for the manuscript "Glucocerebrosidase, a Parkinson´s disease-associated protein, is imported into mitochondria and regulates complex I assembly and function" https://www.researchsquare.com/article/rs-1521848/v1
The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines.
The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines (associated with publication 10.1101/2022.06.01.494130).
Sex-specific microglial responses to glucocerebrosidase inhibition
Morpho-dynamic analysis occurring in primary cells derived from female and male mice in response to proinflammatory stimulations and glucocerebrosidase inhibition.
Differential response of α-synuclein expression to bacterial ligands and metabolites in mouse enteroendocrine cells
Dataset for manuscript ” α-synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells”. Tabs in excel file are title with the figure number.
Data set of the manuscript “Neuronal hyperactivity-induced oxidant stress promotes in vivo a-synuclein brain spreading”
Data set of the manuscript "Neuronal hyperactivity-induced oxidant stress promotes in vivo a-synuclein brain spreading."
Saliva metagenomic data related to “Evaluation of an Adapted Semi-Automated DNA Extraction for Human Salivary Shotgun Metagenomics”
In this study, we proposed a semi-automated DNA extraction protocol for human salivary samples collected with a commercial kit, and compared the outcomes with the DNA extraction recommended by the manufacturer. This study demonstrates that our…
LRRK2-G2019S Synergizes with Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal Degeneration
Dataset collection related to preprint "LRRK2-G2019S Synergizes with Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal Degeneration"
