Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
-
Output Type
-
Program
-
CRN Team Name
-
Theme
Chromatin accessibility profiling (ATAC-seq) of human iPSC-derived midbrain astrocytes in ATP13A2 c.1306 deficiency models
Dataset includes ATAC-seq data comparing WT and ATP13A2 c.1306 mutants in human iPSC-derived midbrain astrocytes to study epigenomic landscape and genome-wide accessibility changes due to genotype.
Transcriptomic profiling of human iPSC-derived midbrain astrocytes in ATP13A2 deficiency (c.1306) models
Dataset compares gene expression in WT and ATP13A2 c.1306 mutants in midbrain astrocytes to understand transcriptional effects on neuroinflammation and lysosome dysfunction linked to early-onset Parkinson's Disease.
DNA methylome profiling (Bisulfite Sequencing) of human iPSC-derived midbrain astrocytes in ATP13A2 c.1306deficiency models
Dataset offers DNA methylation profiles of human midbrain astrocytes comparing ATP13A2 c.1306 mutants with Wild Type controls using WGBS.
quantification data related to “ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity”
quantification data related to "ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity"
Raw data associated with each Figure and Supplementary Figures from “Novel green fluorescent polyamines to analyze ATP13A2 and ATP13A3 activity in the mammalian polyamine transport system”
Raw data associated with each Figure and Supplementary Figures from “Novel green fluorescent polyamines to analyze ATP13A2 and ATP13A3 activity in the mammalian polyamine transport system”
MS proteomics data related to “Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease”
MS proteomics data related to "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease" deposited to the MassIVE repository with the dataset identifier MSV000090202.
metabolomics data related to “Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease”
Neuromodulation such as deep brain stimulation is advancing as a clinical intervention in neurological and neuropsychiatric disorders, including Parkinson's disease. Here, the authors review current literature in the pre-clinical research fields.
Data sets related to “Kufor-Rakeb Syndrome-Associated Psychosis: A Novel Loss-of-Function ATP13A2 Variant and Response to Antipsychotic Therapy”
Data sets related to "Kufor-Rakeb Syndrome-Associated Psychosis: A Novel Loss-of-Function ATP13A2 Variant and Response to Antipsychotic Therapy."
Raw data of ‘The lipid flippase ATP10B enables cellular lipid uptake under stress conditions’
Raw data of 'The lipid flippase ATP10B enables cellular lipid uptake under stress conditions'
Data sets related to “Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits””
Data sets related to "Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits"
WGS data related to “Is Gauchian genotyping of GBA1 variants reliable’
Gauchian software helps identify GBA1 variants but struggles with rare ones due to database limitations, impacting diagnostic accuracy. Data from this study will aid future research on GBA1 variants.
all data related to “Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout”
Raw imaging data for "Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout"
PET-CT related to “Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and parkinsonian motor deficits”
PET-CT related to "Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and parkinsonian motor deficits"
Flow cytometry data related to ‘The lipid flippase ATP10B enables cellular lipid uptake under stress conditions’
Flow cytometry data related to 'The lipid flippase ATP10B enables cellular lipid uptake under stress conditions'
