Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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CRN Team Name
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Source data for Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation
Chen et al (2024) study links α-synuclein aggregation to hyperexcitability in motor cortical neurons.
Source data for the article “α-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice”
α-Synuclein aggregation in mice reduces cortico-amygdala connectivity, leading to impaired social behavior.
Multiscale model of primary motor cortex circuits predicts in vivo cell type-specific, behavioral state-dependent dynamics
The authors developed a multiscale model of mouse primary motor cortex with over 10,000 neurons and 30 million synapses. The model accurately predicted cell type-specific responses associated with behavioral states and experimental manipulations
EPSCs source data across different simulation intensities of thalamus PT, IT neurons, and SC PT neurons
Source data compares EPSCs in thalamus PT, IT neurons, and SC PT neurons between control and 6_OHD mice across varying simulation intensities.
Basal Ganglia Neurons in Healthy and Parkinsonian Primates Generate Recurring Sequences of Spikes
Data consists of interspike intervals from basal ganglia neurons in awake monkeys, pre- and post-parkinsonian treatment with MPTP. Recordings were during spontaneous spiking, without task involvement.
Source data – Cortical PFFs
Source data - Cortical PFF
Calcium imaging in SMA and M1 of macaques
Calcium imaging with miniature microscopes reveals neuron activity patterns in deep layers of SMA and M1, showing synchronous activity and sequential activation.
Sequence analysis outputs
Timings of sequenced calcium events displayed by SMA and M1 neurons.
Jaccard (coactivation) analysis outputs
Jaccard values for calcium transients in M1 and SMA of macaques during spontaneous or task reaching behavior.
General descriptors of calcium activity in M1 and SMA cells
Calcium event rates, IEI CV, and event amplitude were measured in SMA and M1 cells during spontaneous or reaching tasks to analyze neural activity.
Files for GCaMP6f histology images
Files for GCaMP6f histology images
Simulated mouse primary motor cortex activity during control and decreased pyramidal tract neuron excitability in the parkinsonian condition
Sixteen files were collected from 4 sets of simulations, each with control and Parkinsonian conditions in rest and activated states. Parkinsonian M1 simulations showed reduced PT5B neuron excitability. Simulations lasted 4.3 seconds.
Source data for “Sub-second characterization of locomotor activities of mouse models of Parkinsonism”
Source data for "Sub-second analysis of locomotor activity in Parkinsonian mice"
