Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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Program
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Theme
Maintenance of the recording chamber for non-human primate (Chamber cleaning and dura scraping)
This protocol explains two procedures to maintain the recording chamber in nonhuman primates with craniotomies:(1) chamber cleaning and (2) dura scraping.
In Vitro FSCV Testing of Carbon Fiber Electrodes to Characterize Functional Operation in Dopamine Detection
Methods to measure the performance characteristics of carbon fiber electrodes for neurochemical recording.
Characterization of Splay Characteristics of Carbon Fiber Electrode Threads (CFETs) in Agar Brain Phantom
Methods to measure deflection characteristics of carbon fiber electrodes in agar brain phantoms.
Essential surgeries for the electrophysiological recording from a behaving non-human primate brain 1 (Head fixation post and recording chamber implantation)
Protocol for implanting head fixation post and recording chamber in non-human primates for electrophysiological recording.
Histology and Retention of Implanted Carbon Fiber Thread Electrodes in Fixed Tissue
Methods to cut and retain implanted carbon fiber electrodes in brain tissue.
Electrophysiological recording from a chronic chamber-implanted non-human primate
This protocol describes the preparation and insertion of extracellular recording electrodes into intracranial targets of a non-human primate implanted with a chronic recording chamber.
Immunohistochemistry for Carbon Fiber Thread Electrodes
Methods for immunofluorescent staining of brain tissue with indwelling electrodes.
In Vivo Carbon Fiber Electrode Thread (CFET) Implantation and Testing Procedures
Procedures for implanting and testing CFET devices in rats are described.
Essential surgeries for the electrophysiological recording from a behaving non-human primate brain 2 (Craniotomy)
Protocol for performing a craniotomy in a recording chamber on a cranial implant in nonhuman primates.
Standard Operating Procedure (SOP) for Combined ICA and Systemic Administration of MPTP: The Overlesioned (Bilateral Asymmetric) Non-human Primate Model
This standard operating procedure (SOP) describes safe methods for the use of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in non-human primates (adult macaque monkeys).
Standard DAB Staining for Free-floating Fixed NHP Brain Tissue
This protocol details the procedure for immunohistochemical 3,3’-Diaminobenzidine (DAB) staining of free-floating fixed brain tissue sections using the avidin/biotin ABC complex.
DAB Staining for GFP on Free-floating Fixed NHP Brain Tissue
This protocol details the procedure for immunohistochemical 3,3’-Diaminobenzidine (DAB) staining of free-floating fixed brain tissue sections using the avidin/biotin ABC complex to detect green fluorescent protein (GFP).
In-vivo MRI and CT scanning protocol for non-human primates using a 3D printed MR-compatible stereotaxic frame
This protocol describes the methods of using a custom 3D printed stereotaxic frame to acquire MRI and CT scans for nonhuman primates in detailed steps.
Quality assessment for images obtained using 3D printed stereotaxic frame
Protocol assessing MR signal noise/distortion from a 3D printed stereotaxic frame, associated with Liang et al. 2024
Electromyogram recordings for internal capsule stimulations in non-human primates
This protocol outlines steps for performing EMG recordings to confirm implant location during internal capsule stimulation in monkeys. Supplementary to Liang et al. 2024 10.1016/j.jneumeth.2024.110133.
