Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
-
Output Type
-
Program
-
CRN Team Name
-
Theme
Quantification of Axonal Projections from Whole-Brain Slide Images
Quantification of Axonal Projections from Whole-Brain Slide Images provides a standardized method for processing and analyzing immunofluorescence images of mouse brain sections to quantify axonal projections.
LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons
PD LRRK2 influences the effects of haloperidol, a common antipsychotic, on striatal indirect pathway neurons. Inhibiting LRRK2 kinase activity reduces haloperidol’s motor side effects, suggesting a way to ease antipsychotic side effects.
Mass spectrometry proteomics dataset
The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD053892
LRRK2 kinase inhibition restores haloperidol effects on rpS6 signaling in iSPNs
IF images in LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons
LRRK2 regulates haloperidol mediated upregulation of immediate early genes in iSPNs
To define the impact of LRRK2 kinase activity on the expression pattern of Nr4a1 mRNA in the SPNs, we used multicolored single-molecule fluorescence in situ hybridization
Genotyping protocol for mice
This protocol describes the general method to genotype the mice.
Open Field Test Parisiadou Lab
The open field test was developed to test locomotor activity.
Rotarod Test _ Parisiadou Protocol
Motor learning was assessed with an accelerating rotarod.
Dendritic Spine Analysis
Dendritic Spine Analysis for Chen et al. 2025
Striatal sections immunofluorescence and analysis
Striatal sections immunofluorescence and analysis related to LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons
Multicolor fluorescence in situ hybridization and analysis
Multicolor fluorescence in situ hybridization and analysis related to LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons
Drugs and treatment dosing
Drugs and treatment dosing protocol related to LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons
Acute Slice Preparation
ex vivo striatal slices
LC-MS/MS Analysis
LC-MS/MS Analysis related to LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson’s disease vulnerable dopamine axons
Synaptic dysfunctions manifest early in Parkinson's disease. Research on LRRK2 mutations, using advanced genetic models, reveals their effects on neuronal synapses, primarily impacted by the disease, offering insights into potential early therapies.
