Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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CRN Team Name
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Theme
Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala
PD and DLB involve α-syn inclusions in the amygdala affecting cognition and emotions. Cortico-amygdala synapses with α-syn aggregates show increased volume of synapses, potentially contributing to behavioral impairments.
Protocol to study synapse density or volume— SynDOVE—in brain using confocal microscopy and Imaris three-dimensional surface rendering software
Guide for analyzing for analysis of synaptic loci density and pre- and postsynaptic volumes (SynDOVE). from confocal images of pre- and postsynaptic loci in fixed brain sections with Imaris software.
Release Notes – ASAP CRN Cloud – Version 4.0.0
ASAP CRN Cloud released version 4.0.0 with expanded datasets including Human Postmortem-derived Brain Sequencing and Mouse datasets. New collections and individual datasets were added, enhancing PMDBS and Mouse RNA sequencing data.
Spatial transcriptomics reveals molecular dysfunction associated with Lewy pathology
The results identify neurons vulnerable to Lewy pathology in the PD cortex and identify a conserved signature of molecular dysfunction in both mice and humans.
Synaptic Location Is a Determinant of the Detrimental Effects of α-Synuclein Pathology to Glutamatergic Transmission in the Basolateral Amygdala
Study explores α-synuclein's impact on amygdala in Parkinson's. Aggregation affects cortico-BLA transmission, linked to psychiatric deficits in PD.
Vibrational Stabilization of Cluster Synchronization in Oscillator Networks
Restoring normal cluster synchronization is crucial for system functioning. Vibrational control can stabilize synchronization without state measurements, offering a solution for challenging scenarios.
Vibrational Stabilization of Complex Network Systems
Many natural and man-made network systems need to maintain certain patterns, such as working at equilibria or limit cycles, to function properly. The authors provide some numerical results that demonstrate the validity of the theoretical findings.
A topographical atlas of α-synuclein dosage and cell type-specific expression in adult mouse brain and peripheral organs
This atlas provides much-needed insight into the cellular topography of αSyn, and provides a quantitative map to test assumptions about the role of αSyn in network vulnerability in PD and other αSynucleinopathies.
LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread
Mutations in LRRK2 are the most common cause of familial Parkinson’s disease. This work supports a protective role of LRRK2 kinase inhibition in G2019S carriers and provides a workflow for systematic evaluation of brain-wide phenotypes
Whole mount dissection and staining of enteric nervous system
This protocol details whole mount dissection and staining of the enteric nervous system.
Regional Mouse Brain Analysis (Modified QUINT)
This is series of protocols that has been adapted from published and unpublished protocols broadly referred to as the QUINT workflow: QuPath visualization/segmentation QuickNII Brain Atlas Registration QMask Hemispheric Separation Visualign…
ASAP CRN Cloud Release Notes – Version 3.0.0
Summary: Release notes for version 3.0.0 of CRN Cloud platform, released on September 30, 2025, detailing latest updates and enhancements.
Linear diffusion modeling of tau pathology spread
Code to reproduce all network analyses in Lubben et al. “LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread”.
Embryonic/Postnatal Mouse Neuron Culture Protocol
This protocol details the primary neuron culture procedures from embryonic and postnatal mice.
Human Brain Sequential Extraction (Tau)
Human brain sequential detergent fractionation for PHF tau extraction
