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Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Astrocytic polyamine transport by ATP13A4 tunes excitatory synaptic transmission
Polyamines are crucial for brain function. ATP13A4 is the main polyamine transporter in astrocytes, impacting astrocyte morphology, synapse formation, and neurodevelopment. Mutations in ATP13A4 are linked to neurodevelopmental disorders.
An open-source head-fixation and implant-protection system for mice
This study presents a head-fixation and implant-protection system for mice including a headbar, headhat and head fixation station to facilitate experimental procedures in vivo. All 3D-printing files are open source and readily available and editable
Astrocytic LRRK2 Controls Synaptic Connectivity through ERM Phosphorylation
This study shows that the Lrrk2 gene affects astrocyte morphology by regulating ERM protein phosphorylation, which when reduced, restores synaptic function in PD, suggesting astrocytes as potential therapeutic targets.
DART Infusion Protocol
The protocol outlines the procedure for DART (drug acutely restricted by tethering) intracranial infusion in mice
FibPho: Analysis Protocol
Protocol outlines fiber photometry data analysis.
In vivo Electrophysiology Protocol
Protocol outlines method for collecting extracellular single unit dopamine recordings.
Fiber Photometry Protocol
Protocol for fiber photometry collection from VTA dopamine neurons
In vivo Ephys: Spike Sorting Protocol
Protocol outlines spike sorting steps for electrode recording data.
In vivo Ephys: Analysis Protocol
Protocol outlines analysis steps for in vivo electrophysiology data after spike sorting.
Behavior Hardware Setup Protocol
Protocol outlines steps for replicating conditioning/extinction reward learning assay.
Electrophysiological recording from Brain Slices Protocol
Protocol for slice electrophysiological recordings with DART is outlined, providing step-by-step instructions.
VTA Surgery Protocol
Protocol outlines VTA surgery to infect dopamine neurons with virus, and implant cannulas & fibers intracranially in mice
Behavior: Analysis Protocol
The protocol outlines how to visualize and analyze reward learning behavior data for research purposes.
Behavior Protocol
Protocol describes associative learning assay for testing extinction and conditioning behavior in mice.
Histology: Analysis Protocol
Protocol analyzes histology images using Matlab for defining ROIs and ilastik for pixel classification