Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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ASAP CRN Cloud Release Notes – Version 4.0.0
ASAP CRN Cloud released version 4.0.0 with expanded datasets including Human Postmortem-derived Brain Sequencing and Mouse datasets. New harmonized collections and individual datasets were added, enhancing research possibilities.
Adenosine in the brain: recent progress on detection, function and translation
Recent advancements have expanded our understanding of adenosine in the brain, revealing its role in regulating brain circuits for sleep, movement, cognition, and more.
ASAP CRN Cloud Release Notes – Version 2.0.0
Version: 2.0.0 Release Date: December 11, 2024 This release notes document provides a concise overview of the updates and enhancements introduced in Version 2.0.0 of the CRN Cloud platform.
ASAP CRN Cloud Release Notes – Version 1.0.0
Version: 1.0.0 Release Date: June 25, 2024 This release notes document provides a concise overview of the updates and enhancements introduced in Version 1.0.0 of the CRN Cloud platform.
ASAP CRN Cloud Release Notes – Version 1.0.0-beta
Version: 1.0.0-beta Release Date: March 6, 2024 This release notes document provides a concise overview of the updates and enhancements introduced in Version 1.0.0-beta of the CRN Cloud platform.
ASAP CRN Cloud Release Notes – Version 0.0.1
Version: 0.0.1 Release Date: November 10, 2023 This release notes document provides a concise overview of Version 0.0.1 of the CRN Cloud platform.
ASAP CRN Cloud Release Notes – Version 3.0.0
Summary: Release notes for version 3.0.0 of CRN Cloud platform, released on September 30, 2025, detailing latest updates and enhancements.
Datasets and Key Resources Table used in Bouabid, S. et al. (2025) “Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations””
This repository contains a 1) Key Resources Table with details on key resources and the persistent identifiers for protocols and code used and generated in this study; 2) Source Data Folder, and 3) Supplementary Data Folder.
Fabrication and calibration of multi-fiber arrays to monitor dopamine release in the mouse striatum
A new method allows monitoring dopamine release in mice with high spatial and temporal resolution in multiple locations in the striatum simultaneously using a fluorescent sensor. The protocol involves array fabrication and pre-implant mapping.
Micro-CT scanning for post-implant localization of multi-fiber arrays in mouse striatum
New micro-fiber array allows chronic measurement and optogenetic manipulation at 100+ locations in mice, for studying cell-type and neurotransmitter-specific signals in 3-D volumes. Protocol involves micro-CT scanning and fiber localization.
Confocal microscopy to assess TelC and iGluSnFR expression in fixed mouse brain slices
Protocol outlines tissue processing after glutamate recordings with iGluSnFR sensor & behavior experiments post TelC viral injection in dorsal medial striatum.
Custom Phyton scripts related to Bouabid, S. et al (2025) “Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations””
Phyton scripts written by Safa Bouabid and adapted from Han Lab for reading 2D treadmill ball velocity with Raspberry Pi.
Custom MATLAB scripts related to Bouabid, S. et al. (2025) “Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations”
MATLAB scripts written by Safa Bouabid to analyse ACh release dynamics, DA release, glutamate release onto cholinergic interneurons, and behavioural changes in mouse striatum during learning and extinction of Pavlovian associations.
Multi-fiber photometry in head-fixed mice performing a dual-cue delay Pavlovian association
Protocol describes dual-cue Pavlovian association & multi-fiber photometry in head-fixed mice. Mice trained to link cues with rewards & undergo extinction phase with reduced rewards.
Stereotaxic injections of viral vectors and chronic optical fiber implants in mouse brains
Protocol details surgical steps for viral injections and optical fiber implantation in mouse striatum to monitor neurotransmitter dynamics during learning and extinction, using genetic sensors and tetanus toxin to suppress acetylcholine release.
