Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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ASAP CRN Cloud Release Notes – Version 4.0.0
ASAP CRN Cloud released version 4.0.0 with expanded datasets including Human Postmortem-derived Brain Sequencing and Mouse datasets. New harmonized collections and individual datasets were added, enhancing research possibilities.
Dataset for Article “Presynaptic GABAA receptors control integration of nicotinic input onto dopaminergic axons in the striatum” by Brill-Weil et al
Dopaminergic neuron axons have GABAARs and nAChRs that influence DA release. GABAAR antagonism enhances nAChR activity, while picrotoxin inhibits nAChRs, revealing GABAARs' role in regulating nicotinic input onto DA axons.
Primary Tabular Data for article “CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology” by Liao et al
Mitochondrial dysfunction is linked to CHCHD2 mutation, causing altered protein interactions, glycolysis, and ROS, plus α-synuclein aggregation, and neurodegeneration. CHCHD2 accumulation leads to mitochondrial impairment and PD progression.
Processed Proteomics Data for Article “CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology” by Liao et al
Mitochondrial dysfunction is linked to CHCHD2 mutation, causing disrupted protein interactions, metabolic shift to glycolysis, ROS elevation, and α-synuclein aggregation. CHCHD2 accumulation leads to neurodegeneration via impaired respiration.
Human Spatial Transcriptomics data for article “CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology” by Liao et al
Mitochondrial dysfunction in Parkinson's disease involves CHCHD2 mutation leading to disrupted protein interactions, mitochondrial damage, glycolysis shift, increased ROS, and α-synuclein aggregation, linking to neurodegeneration.
ASAP CRN Cloud Release Notes – Version 2.0.0
Version: 2.0.0 Release Date: December 11, 2024 This release notes document provides a concise overview of the updates and enhancements introduced in Version 2.0.0 of the CRN Cloud platform.
ASAP CRN Cloud Release Notes – Version 1.0.0
Version: 1.0.0 Release Date: June 25, 2024 This release notes document provides a concise overview of the updates and enhancements introduced in Version 1.0.0 of the CRN Cloud platform.
ASAP CRN Cloud Release Notes – Version 1.0.0-beta
Version: 1.0.0-beta Release Date: March 6, 2024 This release notes document provides a concise overview of the updates and enhancements introduced in Version 1.0.0-beta of the CRN Cloud platform.
ASAP CRN Cloud Release Notes – Version 0.0.1
Version: 0.0.1 Release Date: November 10, 2023 This release notes document provides a concise overview of Version 0.0.1 of the CRN Cloud platform.
ASAP CRN Cloud Release Notes – Version 3.0.0
Summary: Release notes for version 3.0.0 of CRN Cloud platform, released on September 30, 2025, detailing latest updates and enhancements.
Mouse Behavior – Open Field and T-Maze
This protocol describes two behavioral tasks for mice. The first is the Open Field Test, which is used to asses motor behavior, and the second is the T-Maze, which is used to assess spatial learning.
Live Imaging of Primary Mouse Neuron Cultures
This protocol describes live imaging of primary neuron cultures. Included are methods for preparing hippocampal or dopamine neuronal cultures from neonatal mouse brain tissue. The imaging described involves labeling of dopamine neurons with a…
In Vivo Electrophysiology (Mouse)
This protocol describes the in vivo electrophysiology method for recording neuronal activity in mice.
Immunohistochemistry
This protocol describes immunohistochemical staining of fixed brain sections.
Immunostaining Mouse Brain Tissue or Neuronal Cultures
This protocol describes immunohistochemical and immunoctyochemical methods to analyze protein expression in mouse brain. In the protocol, we describe the fixation of tissue or cultured neurons, the immunostaining procedure, and collecting images for…
