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Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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DAB ANTIBODY (IHC) STAINING PROTOCOL
This is the basic protocol for antibody staining of formalin fixed paraffin embedded (FFPE) tissue.
Ercc1-/∆ mice
This research studies the model of a human progeroid syndrome
CamkIIa-cre;Ercc1-/fl mice
Neurons in the forebrain show elevated DNA damage and potential senescence, suggesting age-related cellular changes in the brain's higher cognitive functions.
Pole Test
The protocol describes the pole test for assessing motor coordination and balance in rodents.
Open Field
This protocol details about Open Field procedure.
Nestin-cre;Ercc1-/fl mice
Pan-neuronal cell types may experience higher levels of internal DNA damage and potential senescence due to various factors.
INTRAMUSCULAR PFF INJECTION
Protocol outlines intramuscular PFF injection in mice.
Loss of tau expression attenuates neurodegeneration associated with α-synucleinopathy
The authors examine the role of tau in the onset and progression of αS pathology using a transgenic mouse model of α-synucleinopathy lacking mouse tau expression.
Th-cre;Ercc1-/fl mice
Dopaminergic neurons may experience elevated DNA damage and potential senescence, suggesting implications for neurodegenerative disorders.
Oligo2-cre;Ercc1-/fl mice
Oligodendrocytes may experience higher levels of DNA damage and potential senescence due to internal factors.
Cx3cr1-cre;Ercc1-/fl mice
Microglia may experience higher levels of DNA damage and potential senescence due to internal factors.
Mouse Perfusion
The protocol outlines the process of mouse perfusion.
ROTAROD PROTOCOL
Protocol detailing the rotarod test procedure for research purposes.
Barnes et al (Preprint-03/24) – Datasets
Datasets connected to Barnes et al can be found in their preprint publication at https://doi.org/10.21203/rs.3.rs-3982325/v1.
Immunofluorescence Staining in Mouse Brain Tissue Sections
Protocol outlines immunofluorescence staining in mouse brain tissue sections.