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Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Source Data and protocols for White, et al 2025- The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract
The manuscript investigates pyrethroid toxicity in enteroendocrine cells and the gastrointestinal tract. It includes source data, statistical output, qPCR gene expression analysis, RNAseq analysis, Metascape pathway analysis, and key resources.
Lewy body diseases and the gut
GI involvement in Lewy body diseases may start with ⍺-synuclein in the gut spreading to the brain. Gut microbiome, immune system, and toxins play roles. These connections could lead to new therapies targeting the gut-brain axis for disease…
Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms
A study on Parkinson's disease links gut microbiome to brain health. Analysis of 490 PD patients and 234 controls reveals dysbiosis, microbial clusters, and disease-promoting factors in PD microbiome, offering insights for future research.
Population fraction of Parkinson’s disease attributable to preventable risk factors
Parkinson's disease is a fast-growing neurologic disease with no known prevention. Environmental factors like head trauma in sports/combat and pesticide exposure contribute significantly to the disease, suggesting preventable causes for some cases.
Gut mucosal cells transfer α-synuclein to the vagus nerve
Published: These findings highlight a potential non-neuronal source of fibrillar α-synuclein protein that might arise in gut mucosal cells. View original preprint.
Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms
Zenodo archive contains post-sequence QC, taxonomic, and functional profiling data. Supplementary Code includes workflow and bioinformatic processing used in the manuscript. Raw sequences and metadata are on NCBI SRA under BioProject ID PRJNA834801.
Population fraction of Parkinson’s disease attributable to preventable risk factors
R-based Posit project for replicating Parkinson's disease risk factor analysis. Includes data in 'input' folder, .Rproj file, renv lockfile, workflow scripts, and output scripts. Refer to README.md for more details.
Characterizing dysbiosis of the Parkinson’s disease gut microbiome using shotgun metagenomics
Parkinson's disease is a progressive neurodegenerative condition with altered gut microbiome composition. A study analyzed fecal samples from 490 PD patients and 234 healthy individuals to understand dysbiosis at a detailed level.
Microbial amyloids in neurodegenerative amyloid diseases
Published: Inhibiting microbial amyloids or their interactions with the host, may therefore represent a tangible target to limit various amyloid pathologies.
Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation
Studies show nanoplastic pollution can trigger α-synuclein protein fibrils formation and spread in the brain, potentially linking nanoplastics to Parkinson's disease and related dementias.
A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative stress, and myelination in a mouse model of colitis
The gut and brain are interconnected in human disease. Colitis models show reproducible genetic programs affecting both colon and brain, highlighting immune activation and potential therapeutic targets in the gut-brain axis.
The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner
Aging is a neglected factor in neurodegeneration research. LRRK2 gene variations impact PD risk.R1441C mutation boosts immune response in young, but leads to immune exhaustion with age.Understanding LRRK2's immune effects is crucial for PD treatment.
Central and peripheral innate and adaptive immunity in Parkinson’s disease
Parkinson’s disease is a chronic inflammatory disorder affecting multiple systems. Innovative immunomodulatory interventions are needed to address central and peripheral immune responses during disease onset and progression.
CryoEM structures of amplified alpha-synuclein fibril class A type I with extended core from DLB case I
Protein fibril classification for Homo sapiens expressed in Escherichia coli BL21(DE3) without mutations.
Calcium influx into astrocytes plays a pivotal role in inflammation-driven behaviors
Systemic inflammation can lead to astrogliosis, affecting neuronal activity linked to depressive behaviors. Orai1 calcium channel is crucial in this.Deleting Orai1 in astrocytes prevents astrogliosis, preserving normal neuronal activity and behavior.