Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data
We systematically investigated experimental and computational design choices for their effects on allelic imbalance analysis in droplet-based snRNA-seq data from human samples. We show that many factors, including read length, sequencing technology,
Single-cell-RNA-seq-of-the-CRISPR-engineered-endogenous-tauopathy-model
Archived Analysis code supporting the study “Transcriptional programs mediating neuronal toxicity and altered glial–neuronal signaling in a Drosophila knock-in tauopathy model.”
TheDongLab/AI2AMP-PD: AI2AMP-PD v1.0
Analysis code to built a novel multi-omics machine learning model to predict PD diagnosis.
Key Resource table related to publication: Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster
The Key resource table contains all software, code and datasets used in the publication.
Raw data of Fig1-7 part of: 3D bioprinting of human neural tissues with functional connectivity
This are the tabular raw data related to the paper "3D bioprinting of human neural tissues with functional connectivity". DOI: 10.1016/j.stem.2023.12.009
G code: 3D bioprinting of human neural tissues with functional connectivity
This is he G code related to the publication Yan et al. 2024 3D bioprinting of human neural tissues with functional connectivity
Lentivirus preparation using Lenti-X Concentrator
This protocol describes the preparation of Lenti-GCaMP6 viral particles using a 2nd generation lentiviral system.
Immunofluorescence and quantification
This protocols describes the immunofluorescence staining and image quantification published in: 3D bioprinting of human neural tissues with functional connectivity DOI: 10.1016/j.stem.2023.12.009
Lenti-jRGECO1b and lenti-iGluSnFR virus preparation
This protocol describes the preparation of EF1-jRGECO1b and EF1-iGluSnFR lentiviral particles using HEK293T cells.
Whole-cell patch-clamp of PSC-derived cortical glutamatergic and GABAergic neurons
This protocol describes whole-cell-patch-clamp of PSC-derived cortical glutamatergic and GABAergic neurons.
Data related to publication: Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model
All tabular data related to the publication Bukhari et al., 2024, Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model are deposited here.
Key Resource Table (KRT) related to publication: Bukhari et al., 2024 Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model
Here you can find the Key resource table realted to the publication: Bukhari et al., 2024 Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model.
Key Resource Table (KRT) related to publication: Nithianandam et al., 2024 Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency
The key resource table includes persistent identifiers for all the data, code, software, protocols and key materials that were used for this manuscript.
Data related to publication: Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency
Tabular data of the publication: Nithianandam et al., 2024, Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency
PD5D_MTG_snRNAseq
This dataset contains single-nucleus RNA sequencing (snRNAseq) raw data in FASTQ format for 94 human middle temporal gyrus (MTG) samples from Parkinson's patients and healthy controls.
