Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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A Multimodal Atlas Reveals the Anatomical Distribution of Medium Spiny Neuron Subtypes and a Novel RGS6+ Population in the Primate Striatum
We combined single-nucleus multi-omic sequencing and high-plex spatial transcriptomics to build a comprehensive atlas of medium spiny neurons (MSNs) across the entire macaque striatum, revealing new MSN subtypes and their association with diseases.
Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents
The authors' CFET array has the potential to unlock a wide range of applications, from uncovering the role of neuromodulators in synaptic plasticity, to addressing safety barriers in clinical translation toward diagnostic and adaptive treatment in PD
Maintenance of the recording chamber for non-human primate (Chamber cleaning and dura scraping)
This protocol explains two procedures to maintain the recording chamber in nonhuman primates with craniotomies:(1) chamber cleaning and (2) dura scraping.
In Vitro FSCV Testing of Carbon Fiber Electrodes to Characterize Functional Operation in Dopamine Detection
Methods to measure the performance characteristics of carbon fiber electrodes for neurochemical recording.
Characterization of Splay Characteristics of Carbon Fiber Electrode Threads (CFETs) in Agar Brain Phantom
Methods to measure deflection characteristics of carbon fiber electrodes in agar brain phantoms.
Essential surgeries for the electrophysiological recording from a behaving non-human primate brain 1 (Head fixation post and recording chamber implantation)
Protocol for implanting head fixation post and recording chamber in non-human primates for electrophysiological recording.
Histology and Retention of Implanted Carbon Fiber Thread Electrodes in Fixed Tissue
Methods to cut and retain implanted carbon fiber electrodes in brain tissue.
Electrophysiological recording from a chronic chamber-implanted non-human primate
This protocol describes the preparation and insertion of extracellular recording electrodes into intracranial targets of a non-human primate implanted with a chronic recording chamber.
Immunohistochemistry for Carbon Fiber Thread Electrodes
Methods for immunofluorescent staining of brain tissue with indwelling electrodes.
In Vivo Carbon Fiber Electrode Thread (CFET) Implantation and Testing Procedures
Procedures for implanting and testing CFET devices in rats are described.
Essential surgeries for the electrophysiological recording from a behaving non-human primate brain 2 (Craniotomy)
Protocol for performing a craniotomy in a recording chamber on a cranial implant in nonhuman primates.
fMRI tasks to explore emotion-motor interactions
Code for fMRI tasks designed to explore emotion-motor interactions—Active Escape and Approach-Avoidance tasks in the Socal Kinesia and Incentivization for Parkinson's Disease (SKIP) dataset.
Incentivized Vigor Task
Code for an fMRI task in which human participants use a joystick to make speeded reaches to cued targets. This task examines incentive effects on movement, part of the Socal Kinesia and Incentivization for Parkinson's Disease (SKIP) dataset.
Evaluation of a novel method for spectral analysis of neurophysiology data
This code implements a novel method for correcting a distortion effect that is present in the power spectra of neuronal spike trains.
Detecting rhythmic spiking through the power spectra of point process model residuals
The work highlighted in this manuscript improves the ability to characterize oscillatory activity and detect pathological changes at the level of individual neurons.
