Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
This study used neuroimaging to show a ventral putamen-centered open-loop circuit linking emotions and movement in humans. Contextual incentives influence which motor circuit is activated, shedding light on paradoxical kinesia in Parkinson's Disease.
Integrated Representations of Threat and Controllability in the Lateral Frontal Pole
Emotions can strongly influence behavior, as seen in PD paradoxical kinesia. Here, we demonstrate that anticipating threats enhances motor accuracy through interactions between the amygdala and the anterior pole of the lateral prefrontal cortex.
Striatal dopamine signals internal states related to behavioral performance over prolonged timescales in monkeys
Dopamine plays dual roles in behavior: fast reward prediction errors and slow motivational states. Dopamine release in monkeys' brain regions tracks performance changes, suggesting a single signal for both functions.
Datasets for Murray et al. 2026 (Prolonged Timescales) Manuscript
Trial information, dopamine data, and autonomic/behavioral data used for the prolonged timescales Murray et al. 2026 manuscript
Neural Control of Autonomic Arousal During Threat Anticipation Revealed by High-Resolution Cardiac Contractility
These findings highlight neural correlates of adaptive behavioral mobilization during emotion-guided action, shedding light on motor circuitry that may be engaged during paradoxical kinesia, a phenomenon of emotion-relevant motor facilitation in PD.
Code for Murray et al. 2026 (Prolonged Timescales) Manuscript
Source code to replicate core analyses used throughout the Murray et al. 2026 (Prolonged Timescales) manuscript.
Data and code for Stasiak et al. 2026 (TREV-Emotion) Manuscript
Online repository for the data and scripts used in the Stasiak et al., 2026 preprint on TREV-derived cardiac contractility in threat anticipation contexts.
Protocol for Stasiak et al. 2026 (TREV-Emotion) Manuscript
Protocol for Stasiak et al. 2026 (TREV-Emotion) Manuscript. Describes participant preparation, shock calibration, scan sequence, active escape task, and participant debriefing.
Distinct amygdalar pathways to frontopolar cortex and medial temporal lobe support temporal memory for emotional events
Amygdala pathways shaped temporal memory for emotional images, some sharpening it, others blurring it. Since related circuits drive paradoxical kinesia in PD, our findings may explain memory and cognitive decline in PD dementia.
Data and code for Active Escape (“Integrated Representations of Threat and Control in the Lateral Frontal Pole”)
Data, Code, and Key Resource Table used in the preprint from Stasiak et al., 2025 ("Integrated Representations of Threat and Control in the Lateral Frontal Pole").
Active Escape Protocol (Stasiak et al., 2026)
Protocol for Active Escape task by Stasiak et al., referenced in "Integrated Representations of Threat and Control in the Lateral Frontal Pole" (2026) manuscript.
Cardiac-sympathetic state predicts action restraint, gated by demonstrated agency
In healthy humans, beat-to-beat cardiac contractility during incentivized reaching predicts action restraint. Cardiac-sympathetic outflow flexibly shapes speed–accuracy tradeoffs under reward and loss contexts, beyond simple action mobilization.
Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents
The authors' CFET array has the potential to unlock a wide range of applications, from uncovering the role of neuromodulators in synaptic plasticity, to addressing safety barriers in clinical translation toward diagnostic and adaptive treatment in PD
Maintenance of the recording chamber for non-human primate (Chamber cleaning and dura scraping)
This protocol explains two procedures to maintain the recording chamber in nonhuman primates with craniotomies:(1) chamber cleaning and (2) dura scraping.
In Vitro FSCV Testing of Carbon Fiber Electrodes to Characterize Functional Operation in Dopamine Detection
Methods to measure the performance characteristics of carbon fiber electrodes for neurochemical recording.
