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Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Microinvasive Probes for Monitoring Electrical and Chemical Neural Activity in Nonhuman Primates
We designed carbon fiber sensors that enable long-term simultaneous recording of both neurochemical and electrical neural activity in deep brain structures of nonhuman primates.
s-µIP Fabrication Process
This protocol describes the fabrication of s-µIP microelectrodes. These devices are made of either one or two parylene-coated tungsten-carbon fiber assemblies, threaded through a silica tube.
Aseptic, semi-sealed cranial chamber implants for chronic multi-channel neurochemical and electrophysiological neural recording in nonhuman primates
We developed an implantable neural interface in monkeys that allows dual monitoring of electrical and chemical neural activity for long-term studies.
Aspiration of Fluid in Semi-Sealed Chamber
Protocol for post-op maintenance of electrode chambers emphasizes fluid aspiration and contamination prevention to reduce infection risk. Regular cleaning is crucial for asepsis and preventing complications like meningitis.
Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents
The authors' CFET array has the potential to unlock a wide range of applications, from uncovering the role of neuromodulators in synaptic plasticity, to addressing safety barriers in clinical translation toward diagnostic and adaptive treatment in PD
Maintenance of the recording chamber for non-human primate (Chamber cleaning and dura scraping)
This protocol explains two procedures to maintain the recording chamber in nonhuman primates with craniotomies:(1) chamber cleaning and (2) dura scraping.
In Vitro FSCV Testing of Carbon Fiber Electrodes to Characterize Functional Operation in Dopamine Detection
Methods to measure the performance characteristics of carbon fiber electrodes for neurochemical recording.
Characterization of Splay Characteristics of Carbon Fiber Electrode Threads (CFETs) in Agar Brain Phantom
Methods to measure deflection characteristics of carbon fiber electrodes in agar brain phantoms.
Essential surgeries for the electrophysiological recording from a behaving non-human primate brain 1 (Head fixation post and recording chamber implantation)
Protocol for implanting head fixation post and recording chamber in non-human primates for electrophysiological recording.
Histology and Retention of Implanted Carbon Fiber Thread Electrodes in Fixed Tissue
Methods to cut and retain implanted carbon fiber electrodes in brain tissue.
Electrophysiological recording from a chronic chamber-implanted non-human primate
This protocol describes the preparation and insertion of extracellular recording electrodes into intracranial targets of a non-human primate implanted with a chronic recording chamber.
Immunohistochemistry for Carbon Fiber Thread Electrodes
Methods for immunofluorescent staining of brain tissue with indwelling electrodes.
In Vivo Carbon Fiber Electrode Thread (CFET) Implantation and Testing Procedures
Procedures for implanting and testing CFET devices in rats are described.
Essential surgeries for the electrophysiological recording from a behaving non-human primate brain 2 (Craniotomy)
Protocol for performing a craniotomy in a recording chamber on a cranial implant in nonhuman primates.
fMRI tasks to explore emotion-motor interactions
Code for fMRI tasks designed to explore emotion-motor interactions—Active Escape and Approach-Avoidance tasks in the Socal Kinesia and Incentivization for Parkinson's Disease (SKIP) dataset.