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Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Leveraging animal models to understand non-motor symptoms of Parkinson’s disease
Parkinson's disease diagnosis focuses on motor symptoms, but non-motor symptoms like cognitive issues and sleep disorders significantly affect patients. Research on non-motor signs in animals aims to improve understanding of the disease.
Non-human Primate Arm-reaching Behavioral Tasks
Protocol for training and testing non-human primates in arm-reaching tasks to evaluate parkinsonian animals
Standard Operating Procedure (SOP) for systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in non-human primates
This protocol details standard operating procedure (SOP) for systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in non-human primates.
Brain Slice Preparation for electrophysiology recording
This protocol describes brain slice preparation for electrophysiology recording.
Confocal imaging and digital image analysis
Protocol for confocal imaging on Nikon A1R microscope & digital image analysis is detailed.
Multiscale model of primary motor cortex circuits predicts in vivo cell type-specific, behavioral state-dependent dynamics
The authors developed a multiscale model of mouse primary motor cortex with over 10,000 neurons and 30 million synapses. The model accurately predicted cell type-specific responses associated with behavioral states and experimental manipulations
Perfusion-fixation procedure for adult rhesus monkeys
The protocol details the perfusion-fixation procedure for rhesus monkeys
EPSCs source data across different simulation intensities of thalamus PT, IT neurons, and SC PT neurons
Source data compares EPSCs in thalamus PT, IT neurons, and SC PT neurons between control and 6_OHD mice across varying simulation intensities.
Standard Operating Procedure: Mouse Stereotaxic Intracranial Injection Surgery
SOP outlines procedures for mouse stereotaxic intracranial injection surgery.
Basal Ganglia Neurons in Healthy and Parkinsonian Primates Generate Recurring Sequences of Spikes
Data consists of interspike intervals from basal ganglia neurons in awake monkeys, pre- and post-parkinsonian treatment with MPTP. Recordings were during spontaneous spiking, without task involvement.
Multiscale model of primary motor cortex circuits predicts in vivo cell type-specific, behavioral state-dependent dynamics
A detailed multiscale model of mouse primary motor cortex accurately predicted responses to behavioral states and manipulations, aiding in understanding cortical function at different scales.
Immunohistochemistry Protocol – Chu lab (Wichman)
This protocol describes immunohistochemistry.
Simulations predict differing phase responses to excitation vs. inhibition intheta-resonant pyramidal neurons
This research highlights how cortical neurons respond differently to oscillatory inputs, impacting neuronal responses to network state shifts.
Light microscopy immunoperoxidase staining
Protocol for Light microscopy immunoperoxidase staining.
Standard Operating Procedure: Mouse transcardiac perfusion protocol
Mouse transcardiac perfusion protocol and storage.