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Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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pAAV-pCAG-Floxed-SynGFP,rev.-WPRE (e.g. AAV-flex-SynTag)
CAG-driven, Cre-dependent synaptophysin-tagged GFP for anterograde tracing of neuronal projections.
pAAV-pCAG-iCRE-2A-H2BGFP-WPRE (e.g. AAViCre-H2B-GFP)
CAG-driven Cre recombinase coupled with H2B-GFP for nuclear fluorescent labelling
pAAV-pCAG-Floxed-FlpO-2A-H2BV5c.o.,rev.-WPRE (e.g. AAV-flex-FlpO-H2B-V5)
Plasmid is CAG-driven, Cre-dependent FlpO recombinase for H2B-V5.
pAAV-pCAG-FRT(F3F5)-ChRmine3.3-p2A-oScarlet,rev.-WPRE (e.g. AAV-FRT-ChRmine-p2a-oScarlet)
Plasmid is CAG-driven, Flp-dependent ChRmine for optogenetic excitation of neurons with an oScarlet tag.
Dynamic basal ganglia output signals license and suppress forelimb movements-Datasets
This repository contains the datasets and analysis files associated with the study by Falasconi, Kanodia, and Arber (2025).
Dynamic basal ganglia output signals license and suppress forelimb movements
Basal ganglia is fundamental to motor control and dysfunction is linked to motor deficits. Our results demonstrate the existence and function of highly specific and temporally precise movement representations in basal ganglia output circuitry.
Mouse Stereotaxic Surgery-Arber Lab
This protocol describes the steps for performing stereotaxic surgery in mice. It is applicable to intracranial injections (e.g. virus, drug) and placement of implants (e.g. optical fibers, electrode arrays) into targeted regions of mouse brains.
AAV Production Protocol-Arber Lab
AAV Production methods used in Falasconi & Kanodia et al 2025 and is the general protocol for Arber Lab.
Immunohistochemistry & Microscopy-Falasconi & Kanodia et al 2025
Immunohistochemistry and microscopy methods used in Falasconi & Kanodia et al 2025.
Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses I
This dataset provides a unifying logic for how the developmental specification of diverse SNr neurons relates to the anatomical organization of basal ganglia circuits controlling specialized downstream brain regions.
Single nucleus RNA sequencing of SNr neurons
These findings provide a unifying logic for how the developmental specification of diverse SNr neurons relates to the anatomical organization of basal ganglia circuits controlling specialized downstream brain regions.
pAAVDJ-CAG-FlpX-mKate2.0-N2cG
The pAAV-CAG-fDIO-mKate2.0-N2cG vector was used as a helper virus in conjunction with a rabies virus to label presynaptic inputs to various regions in the brain with focus on SNr neurons.
Histology Fushiki et al 2024
Histology protocol for Fushiki et al 2024 , to quantify Th+ cells and visualize the dorsal-tier or ventral-tier of SNc DANs.
Open Field & Cylinder test Behavior Assays
Protocols for mouse behavioral studies using the open field test and the cylinder test from Fushiki et al 2024.
Single-cell RNA-sequencing data from A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease
Single-nucleus RNA profiling of the ventral midbrain of MitoPark mice, their littermate controls and C57BL/6 mice at 8, 16, and 24 weeks of age (8 mice in each group; 4 males and 4 females).