Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Output Type
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Program
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CRN Team Name
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Theme
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson’s disease
LID is poorly understood, our research on dyskinetic mice show SPNs' properties oscillate during LID and are influenced by dopamine and acetylcholine signaling. Targeting M1 receptors in iSPNs reduced LID severity and improved levodopa effects.
EnvA-N2c-deltaG-H2B-HA-FlpO
Generated for anatomical anterograde tracing experiments by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201).
FushikiA_etal_2024: PD Model Mice Study – v1.0 Code
Repository offers tools for processing, analyzing, and visualizing data related to PD and dopaminergic neurons.
pAAVDJ-Ef1a-FDOI-mScarlet
Generated for anatomical tracing experiments by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201).
Pavlovian protocol – Fushiki et al 2024
Pavlovian Conditioning Protocols for Mouse Behavioral Studies Derived from Fushiki et al 2024.
Datasets for Belal et al. ‘Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models’
Deposit contains processed data spreadsheets and SVG figure panels generated from the raw electrophysiology, imaging and in-situ hybridization recordings.
Mathematica code for Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra
Mathematica notebook containing functions used to measure spikerates, draw histograms, and extract current traces from Clampfit raw data exports.
Dandiet: Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in Substanta nigra
This is a Dandiet that hosts binary files of electrophysiology data for the titled manuscipt 'Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in Substanta nigra'.
Fushiki et al – Video Recording of Parkinson’s Disease Model Mice
Raw behavioral datasets and experimental video recordings referenced in the paper( https://www.biorxiv.org/content/10.1101/2024.12.20.629776v1).
Imaging Dataset for: A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson’s Disease
Dataset includes imaging data from experiments detailed in PMID: 39763754. Coronal brain sections imaged with fluorescence microscopy to assess reporter and transgene expression.
EMG fabrication in Rodrigues-Vaz & Athalye et al
This is the protocol for fabrication of EMG electrodes for bulk muscle recordings used for Rodrigues-Vaz and Athalye et al, 2025 and based on Akay et al, 2006.
Histology from Rodrigues-Vaz and Athalye et al: Imaging of specific mouse brain region where viral injection and implant was placed at
This dataset is part of an experiment in which dorsolateral striatum (DLS) was imaged while mice performed task. This images show targeting of viral expression and lens implant to DLS.
Virus Injections from Rodrigues-Vaz & Athalye et al
This is the standard stereotaxic/Nanoject injection mouse surgery protocol for Rodrigues-Vaz and Athalye et al, 2025.
Code used to analyze striatum population dynamics during isometric forelimb actions
Code used for analysis and figures for paper titled: "Striatal ensembles specify and control granular forelimb actions".
2-photon imaging raw data from striatal populations through GRIN lens
The neuronal activity of striatal cells was acquired while the mouse performed a two-action isometric forelimb force task.
