ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.


Coating coverslips for cell culture

Coated coverslips provide a nourishing adherent surface for cell culture. This protocol provides step by step instruction on how to coat coverslips for cell culture.


Dopaminergic axons track somatic signaling in behaving mice

Preprint: Striatal dopamine released from the axons of midbrain dopamine neurons has been linked to a wide range of functions, including movement control and reward-based learning. Here, authors used genetic strategies to isolate key dopaminergic neuron subtypes and monitor their axonal and somatic signaling patterns in behaving mice.


Molecular heterogeneity in the substantia nigra: a roadmap for understanding PD motor pathophysiology

Review: This article discusses the existing knowledge of DA neuron subtypes and attempts to provide a roadmap for how their distinctive properties can provide novel insights into the motor symptoms of Parkinson’s disease (PD).


LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights

Review: This review focuses on pathogenic LRRK2 mutations and their effects on striatial neurons.


R1441C and G2019S LRRK2 knock-in mice have distinct striatal molecular, physiological, and behavioral alterations

Publication: LRRK2 mutations are closely associated with PD. Convergent evidence suggests that LRRK2 regulates striatal function. Here, by using knock-in mouse lines expressing the two most common LRRK2 pathogenic mutations – G2019S and R1441C – the authors investigated how LRRK2 mutations altered striatal physiology. View original preprint.