Complex Disease Network

Parkinson’s disease (PD) is a complex neurodegenerative disease with a variety of genetic and environmental factors contributing to this disease. In the past decade, great progress has been made in identifying genetic risk for complex PD (or sporadic/idiopathic PD). Using genome-wide association studies (GWAS), around 90 independent risk factors have been identified, including widely known variants in gene regions from GBA, LRRK2, and SNCA.

We aim to dramatically expand this work and identify and dissect the genetic risk underlying PD by genotyping >150,000 DNA samples with a specific focus on underrepresented populations. By forming a large network of researchers across the globe that will provide data and DNA samples and by allowing open and democratic access to data, we hope to accelerate scientific discovery in PD. Our main mission is coordinating and organizing the complex arm of GP2, comprised of the groups Cohort Integration and Data Analysis.

Working Group
Andrew B. Singleton, PhD
Biography
Lead Complex Disease

Andrew B. Singleton, PhD

National Institutes of Health | USA
Cornelis Blauwendraat, PhD
Biography
Co-Lead Complex Disease

Cornelis Blauwendraat, PhD

National Institutes of Health | USA
Caroline Pantazis, PhD
Biography

Caroline Pantazis, PhD

National Institutes of Health | USA
Milestones
Progress so far
Remaining Year 1 Goals
  • Start genotyping GP2 samples (aim is to genotype 15K samples before the end of 2020)

Contact Us

Please contact us if you would like to know more or if you have any questions: info@gp2.org.