Reconstitution of multistep recruitment of ULK1 to membranes in autophagy
By onULK1C and PI3KC3-C1 work together to start autophagy. This work establishes a stepwise pathway for recruitment of the ULK1 KD to the vicinity of the membrane surface downstream of PI3KC3-C1 to initiate autophagy.
Pathway and gates for ATG2A-mediated lipid transport in autophagy
By onATG2A ransfers lipids between donor and acceptor membranes leading to autophagosome formation. This study suggests that ATG2A is a lipid transporter gated at the N-terminus by blocking helices that, upon release, act as additional membrane tethers.
Microbiome signature of Parkinson disease in healthy and genetically at-risk individuals
By onParkinson's disease (PD) is disabling and costly. *GBA1* variants increase PD risk. Gut microbiome changes can predict PD progression and identify those at risk, suggesting potential for disease modification through nutrition.
Code R script related to doi.org/10.1038/s41531-025-01063-3
By onSevere GBA1 variants are linked to Parkinson's disease, impacting counseling and clinical trials. Access R script at doi.org/10.1038/s41531-025-01063-3 for more details.
Clinical data associated with doi.org/10.1038/s41531-025-01063-3
By onStudy shows severe *GBA1* variants contribute to Parkinson's Disease phenotype, impacting counseling and clinical trials. Findings available at doi.org/10.1038/s41531-025-01063-3.
Read Alignment table associated with doi.org/10.3389/fnins.2025.1546203
By onSummary: The publication explores the link between the *GBA1* host genotype and gut microbiome in the *GBA1*L444P/WT mouse model, shedding light on Parkinson's disease development.
MSP abundance table associated with doi.org/10.3389/fnins.2025.1546203
By onSummary: The table displays the abundance of microbial species in the gut of GBA1 L444P/WT mouse model, exploring the connection between GBA1 host genotype and gut microbiome in Parkinson's disease research.
Metagenomics sequencing data of publication doi.org/10.3389/fnins.2025.1546203
By onThe study explores the connection between *GBA1* gene variants and gut microbiome in a mouse model, shedding light on Parkinson's disease development.
G2 Single Guide RNA for TMEM55B CRISPR-Cas9 KO cell generation
By onGuide RNA G2 used to knockout TMEM55B gene in CRISPR-Cas9 system for cell line generation.
G1 Single Guide RNA for TMEM55B CRISPR-Cas9 KO cell generation
By onGuide RNA G1 used to knockout TMEM55B gene in CRISPR-Cas9 system for cell line generation.
Anti-sense A Guide RNA for TMEM55B CRISPR-Cas9 KO cell generation
By onA guide for creating Tmem55B Crispr-Cas9 KO, targeting the antisense strand to disrupt gene function efficiently.
Sense A Guide RNA for TMEM55B CRISPR-Cas9 KO cell generation
By onA guide for Tmem55B Crispr-Cas9 knockout.
