Bolen Human Sigmoid Colon RNA CosMx Dataset
By onNanoString CosMx RNA dataset from human sigmoid colon of healthy controls, Parkinson's Disease, or inflammatory bowel disease exported for analysis.
Bolen Human Sigmoid Colon Protein CosMx Datasets
By onProtein dataset from NanoString CosMx includes sigmoid colon samples from healthy controls, Parkinson's disease, and inflammatory bowel disease patients for analysis.
Tansey Plasma Meso Scale Discovery
By onPlasma samples from individuals with Parkinson's disease, inflammatory bowel disease, or healthy controls were analyzed to measure chemokines and cytokines. The study used Quickplex MSD instrument following manufacturer's protocol.
Tansey Stool Meso Scale Discovery
By onStool samples of healthy controls and individuals with either PD or IBD analyzed for chemokines, cytokines, and ferritin levels using U-PLEX and R-PLEX assays on Quickplex MSD instrument.
Bolen CosMx human Colon RNA and Protein code
By onRepository for the paper "Spatial single-cell multiomics..." includes CosMx assays, README files with scripts/data for analysis, and computational environment requirements. It also features a tissue microarray image showing morphology markers.
Multi-omics reveal critical differentiation target for Parkinson’s Disease-vulnerable midbrain dopaminergic neurons
By onWe describe a multiomic-guided strategy that enriches SOX6+ mDA neurons by combining enhancing Sonic Hedgehog agonism with prolonged Wnt activation. This work is a reproducible differentiation platform for generating the PD-susceptible mDA subtype
G2 Single Guide RNA for TMEM55A CRISPR-Cas9 KO cell generation
By onG2 Single Guide RNA used for generating TMEM55A CRISPR-Cas9 knockout cells.
G1 Single Guide RNA for TMEM55A CRISPR-Cas9 KO cell generation
By onA single guide RNA (sgRNA) targeting TMEM55A gene is used for CRISPR-Cas9 knockout (KO) in cells.
Sense A Guide RNA for TMEM55A CRISPR-Cas9 KO cell generation
By onA guide for using CRISPR-Cas9 to knockout Tmem55A gene, providing instructions on designing sgRNA sequences and conducting gene editing experiments efficiently.
Anti-sense A Guide RNA for TMEM55A CRISPR-Cas9 KO cell generation
By onA guide for using Crispr-Cas9 to knockout Tmem55A gene, providing instructions for creating anti-sense oligonucleotides for gene editing.
Jess western blot automated system
By onBrief description of preparation of samples for Jess western blot automated system. Detailed instructions are included with the reagent pack
western blot data of ‘A new selection strategy to enrich dopaminergic neurons facilitates comparisons between patient iPSC-derived lines’
By onwestern blot data of 'A new selection strategy to enrich dopaminergic neurons facilitates comparisons between patient iPSC-derived lines'
ASAP CRN Cloud Release Notes – Version 4.0.0
By onASAP CRN Cloud released version 4.0.0 with expanded datasets including Human Postmortem-derived Brain Sequencing and Mouse datasets. New harmonized collections and individual datasets were added, enhancing research possibilities.
Matters arising: Forced Symmetry Artifacts in a Prohibitin Complex Structure
By onLange et al. proposed a model for mitochondrial prohibitin complex with unequal subunit stoichiometry. Data suggests an asymmetric structure, questioning the validity of the proposed model. Care is needed in symmetry imposition in cryo-ET.
