Mitochondrial dysfunction is linked to CHCHD2 mutation, causing disrupted protein interactions, metabolic shift to glycolysis, ROS elevation, and α-synuclein aggregation. CHCHD2 accumulation leads to neurodegeneration via impaired respiration.
Protein dataset from NanoString CosMx includes sigmoid colon samples from healthy controls, Parkinson's disease, and inflammatory bowel disease patients for analysis.
