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Datasets and Key Resource Table for Lunn et al., 2026: Elevated phosphorylated α-synuclein and phosphorylated-tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis

By Michaela Lunn, Karan Thakur, Nathalie Lengacher, Quinton Hake-Volling, aSCENT-PD Investigators, Julianna Tomlinson, PhD, Subash Sad, Earl Brown, Michael Schlossmacher, MD
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Output Details

Description
This entry contains the raw data and key resource files for the manuscript Lunn M., et al 2026: Elevated phosphorylated α-synuclein and phosphorylated-tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis
Identifier (DOI)
10.5281/zenodo.16576378
Tags
  • Alpha-synuclein
  • ELISA
  • Infection models
  • LRRK2-G2019S
  • Mouse
  • Other
  • Oxidative stress
  • Phosphorylated tau
  • Western Blot
Discovery Team
Team Schlossmacher
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

  • User avatar fallback logo

    Michaela Lunn

    External Collaborator

  • User avatar fallback logo

    Karan Thakur

    External Collaborator

  • User avatar fallback logo

    Nathalie Lengacher

    External Collaborator

  • User avatar fallback logo

    Quinton Hake-Volling

    External Collaborator

  • User avatar fallback logo

    aSCENT-PD Investigators

    External Collaborator

  • Julianna Tomlinson, PhD

    Project Manager: Team Schlossmacher, 

    Ottawa Hospital

  • User avatar fallback logo

    Subash Sad

    External Collaborator

  • User avatar fallback logo

    Earl Brown

    External Collaborator

  • Michael Schlossmacher, MD

    Lead PI (Core Leadership): Team Schlossmacher, 

    The Ottawa Hospital

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Elevated phosphorylated α-synuclein and phosphorylated tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis

Influenza virus infection does not alter acute sickness in mice with Lrrk2 mutations. Surviving Lrrk2 p.G2019S KI mice, however, had elevated oxidative stress and phosphorylated a-synuclein and tau proteins in their brains six weeks post-infection.

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Elevated phosphorylated α-synuclein and phosphorylated tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis

Influenza virus infection does not alter acute sickness in mice with Lrrk2 mutations. Surviving Lrrk2 p.G2019S KI mice, however, had elevated oxidative stress and phosphorylated a-synuclein and tau proteins in their brains six weeks post-infection.

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Aligning Science Across Parkinson's
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