ASA-PD (Advanced Sensing of Aggregates - PD) is a new imaging method to map α-synuclein oligomers in human brain tissue, revealing specific early proteinopathy markers in PD patients. This may aid in understanding disease mechanisms.
PD and DLB involve α-syn inclusions in the amygdala affecting cognition and emotions. Cortico-amygdala synapses with α-syn aggregates show increased volume of synapses, potentially contributing to behavioral impairments.
