Ex Vivo Electrophysiology – Ford Lab

By Beatriz Elizabeth Nielsen, PhD and Chris Ford, PhD
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Output Details

Description
This protocol describes the steps to perform whole-cell electrophysiology recordings in acute brain slices.
Identifier (DOI)
10.17504/protocols.io.j8nlkooowv5r/v1
Tags
  • Electrophysiology
Team
Team Edwards
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

  • Beatriz Elizabeth Nielsen, PhD

    Key Personnel: Team Edwards, 

    University of Colorado Anschutz Medical Campus

  • Chris Ford, PhD

    Collaborating PI: Team Edwards, 

    University of Colorado

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Preparation of Acute Brain Slices

This protocol describes the steps for preparing acute brain slices.

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Postsynaptic adaptations in direct pathway muscarinic M4-receptor signaling follow the temporal and regional pattern of dopaminergic degeneration

Imbalances in dorsal striatum output in Parkinson's disease are driven by dopamine loss and disrupted acetylcholine signaling. These changes occur in response to dopamine loss, affecting M4 receptors in striatal neurons, crucial for PD progression.

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