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Liquid Chromatography-Mass Spectrometry (LCMS) with striatal synaptosomes

By Chuyu Chen, PhD, Loukia Parisiadou, PhD
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Output Details

Description
We and others previously reported that knock-in mice expressing the pathogenic hyperactive Lrrk2G2019S mutation exhibit deficits in dopamine release within the striatum. To investigate the underlying molecular mechanisms, we conducted quantitative phosphoproteomic Liquid Chromatography-Mass Spectrometry (LC-MS) studies on striatal synaptosomes from Lrrk2G2019S mice.
Identifier (DOI)
10.17504/protocols.io.eq2lyqk6mvx9/v1
Team
Team Awatramani
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

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