Clinical data associated with doi.org/10.1038/s41531-025-01063-3
By onStudy shows severe *GBA1* variants contribute to Parkinson's Disease phenotype, impacting counseling and clinical trials. Findings available at doi.org/10.1038/s41531-025-01063-3.
Datasets of Introducing PIGMO, a novel PIGmented MOuse model of Parkinson’s disease
By onThere is a pressing need for the development of animal models of PD that properly mimic the its cardinal features. Here an AAV engineered to bypass the blood-brain barrier and coding for the human tyrosinase gene is used to generate the PIGMO model.
Datasets and Key Resources Table used in Bouabid, S. et al. (2025) “Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations””
By onThis repository contains a 1) Key Resources Table with details on key resources and the persistent identifiers for protocols and code used and generated in this study; 2) Source Data Folder, and 3) Supplementary Data Folder.
Motor behavior, GI behavior, protein, and volatile fatty acid assay data and analysis code associated with Moiseyenko et al. 2025
By onCode and data used for the statistical analysis of motor behavior and gut physiology tests, and downstream protein assays from Moiseyenko et al. (2025)
In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson’s disease
By onUsing a newly developed rodent model, the authors assessed whether the intracellular buildup of neuromelanin that occurs with age can be slowed down in vivo to prevent or attenuate Parkinson’s disease.
Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease
By onAuxilin participates in clathrin uncoating to facilitate presynaptic endocytosis. Loss-of-function mutations of auxilin (PARK19) cause Parkinson’s disease. Using auxilin KO mice, Vidyadhara et al. (2023) show that synaptic vesicle sorting deficits, cytoplasmic dopamine accumulation, dopamine transporter mistrafficking, and synaptic autophagic overload may lead to pathogenesis of Parkinson’s disease in PARK19 patients. This file contains the data set used to generate all the main figures.
Tabular data of striatal motor learning experiments in LRRK2 KI mice
By onThe tabular data of the behavioral experiments described in the manuscript titled "R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations."
Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates
By onEvidence shows that intracellular aggregation of endogenous alpha-synuclein is triggered by NMel accumulation. Any therapeutic approach to decrease NMel levels may provide appealing choices for the successful implementation of novel PD therapeutics.
Development and characterization of a non-human primate model of disseminated synucleinopathy
By onThe performance and biodistribution of the retrogradely-spreading AAV9-SynA53T vector was evaluated in the NHP brain. Deliveries of viral suspensions in the left putamen gave rise to a disseminated synucleinopathy in a circuit-specific basis.
Dynamic behaviour restructuring mediates dopamine-dependent credit assignment Creators
By onSource Data for Nature manuscript: Dynamic behaviour restructuring mediates dopamine-dependent credit assignment
Source Data for Mendonça et al 2024
By onSource data and code from dopamine neuron activity encode the length of upcoming contralateral movement sequences by Mendonça et al 2024.
Reward perseveration is shaped by GABAA-mediated dopamine pauses: Behavior Data
By onBehavioral raw data included in MATLAB files with associated extracted analyses for the "Reward perseveration is shaped by GABAA-mediated dopamine pauses" study
Reward perseveration is shaped by GABAA-mediated dopamine pauses: Fiber Photometry Data
By onDataset containing the raw fiber photometry, behavior data, histological images, ROIs and corresponding analysis for the findings in "Reward perseveration is shaped by GABAA-mediated dopamine pauses" study
An Open Source Head-Fixation and Implant-Protection System for Mice – Dataset
By onWe provide 3D-printing files, detail vendors and software used to make the components of the system, and provide editable design files for maximum flexibility to individual lab requirements.
Dataset for: Development of a Simplified Smell Test to Identify Patients with Typical Parkinson’s as Informed by Multiple Cohorts, Machine Learning and External Validation
By onClinical dataset relating to analysis of olfaction from multiple Parkinson disease cohorts. Olfactory performance was analyzed to create a simplified smell test as a screening tool for Parkinson disease and other forms of parkinsonism.
Dautan et al 2024 ” Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson’s Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder”
By onThis zenodo record contains the raw data for the preprint including raw data csv files, images, matlab codes, imageJ macros, and Prism analysis files. See the README files for more details.
Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits
By onModels for neurodegenerative diseases lack of NM, a pigment found in human brains. A new transgenic mouse model, mimics human distribution and shows age-related neuronal dysfunction and degeneration, offering potential for research in brain aging .
Data for Published Paper “Chronic Hyperactivation of Midbrain Dopamine Neurons Causes Preferential Dopamine Neuron Degeneration”
By onRaw Data for publication titled "Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration."
Primary Data for Article “Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input” (DOI: 10.1016/j.celrep.2024.114483)
By onPrimary data for the published manuscript "Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input" (Ryan et al. Cell Reports 43:8, 114483, 2024.)
Raw files for Part2: Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
By onAll data presented in Figure 2
