Impact of the dopamine system on long-term cognitive impairment in Parkinson disease: an exploratory study

By Daniel Weintraub, Marina Picillo, Hyunkeun Ryan Cho, Chelsea Caspell-Garcia, Cornelis Blauwendraat, PhD, Ethan G Brown, Lana M. Chahine, Christopher S. Coffey, Roseanne D. Dobkin, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Ken Marek, MD, Kalpana Merchant, PhD, Brit Mollenhauer , MD, Kathleen Poston, MD, Tanya Simuni, MD, Andrew Siderowf, Andrew Singleton, PhD, John Seibyl and Caroline M. Tanner
Published April 10, 2023
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Output Details

Published April 10, 2023

Description
Background Little is known about the impact of the dopamine system on development of cognitive impairment (CI) in Parkinson disease (PD). Using data from a multi-site, international, prospective cohort study, authors explored the impact of dopamine system-related biomarkers on CI in PD. The study provides preliminary evidence that alterations in the dopamine system predict the development of clinically-relevant, cognitive impairment in Parkinson's disease. If replicated and determined to be causative, they demonstrate that the dopamine system is instrumental to cognitive health status throughout the disease course.
Identifier (DOI)
10.1002/mdc3.13751
Tags
  • Cognitive decline
  • Cognitive dysfunction/dementia
  • Dopamine
  • Imaging
  • Original Research
Program
Parkinson's Progression Markers Initiative

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