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Output Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
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Plasmid construction – Chen et al. 2025 NSMB
Standard cloning procedure.
Image Processing and 3D Reconstruction – Chen et al. 2025 NSMB
Image processing and 3D reconstruction applied in Chen et al. 2025 NSMB
Mass photometry V.2
A protocol for performing mass photometry measurements.
EMD-40658
Structure of human ULK1 complex core (2:1:1 stoichiometry)
EMD-45297
Structure of human ULK1C:PI3KC3-C1 supercomplex
EMD-40715
Structure of human ULK1 complex core (2:2:2 stoichiometry) in the PI3KC3-C1 mixture
EMD-40735
Structure of human ULK1 complex core (2:2:2 stoichiometry) of the ATG13(450-517) mutant
8SQZ
Structure of human ULK1 complex core (2:2:2 stoichiometry) in the PI3KC3-C1 mixture
Protocols for Goldman et al. 2025
All protocols related to GEM-SCOPe and described in Glodman et al. 2025
all data related to “Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout”
Raw imaging data for "Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout"
Neuromelanin and selective neuronal vulnerability to Parkinson’s disease
Neuromelanine (NM), a pigment in human catecholamine neurons, plays a crucial role in PD. We review the development of NM in dopamine versus noradrenaline neurons and focus on previously overlooked cellular organelles in NM format and function.
Reply to: Is Gauchian genotyping of GBA1 variants reliable?
Summarizing a study by N. Tayebi et al. in Communications Biology, published in 2025.
Dynamic basal ganglia output signals license and suppress forelimb movements-Datasets
This repository contains the datasets and analysis files associated with the study by Falasconi, Kanodia, and Arber (2025).
End-product inhibition of the LRRK2-counteracting PPM1H phosphatase
PPM1H phosphatase reverses Rab GTPase phosphorylation by LRRK2 in Parkinson's disease. PPM1H binds Rab8A and Rab10 at an allosteric site, inhibiting phosphatase activity. Targeting this site may offer a therapeutic strategy.
Characterizing Parkinson’s Disease Clinical and Biomarker Interactions in REM Sleep Behavior Disorder
a-syn SAA positivity, DaT positivity, and hyposmia are highly associated with each other. MDS Prodromal PD Probability scores may be useful predictors of near-term progression, and thus as a stratification factor in clinical research study design