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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Article
Astrocytic LRRK2 controls synaptic connectivity through ERM phosphorylation
This work reveals a causal link between the astrocytic and synaptic dysfunction induced by the PD-linked mutation, LRRK2 G2019S, providing a non-cell autonomous mechanism for rescuing aberrant cortical wiring
Teams
Article
The integrated stress response in brain diseases: A double-edged sword for proteostasis and synapses
The integrated stress response (ISR) is a conserved biochemical pathway that regulates protein synthesis. As such, the ISR is implicated in a wide range of diseases, including brain disorders. In this review, the authors consider the ISR’s contribution to brain disorders through the lens of its potential effects on synaptic plasticity.
Teams
Article
SynBot: An open-source image analysis software for automated quantification of synapses
Quantifying the number of synapses from light microscopy images enables screening the impacts of experimental manipulations on synapse development. This approach utilizes low-throughput analysis methods that are challenging to learn and results are variable between experimenters. The authors developed SynBot, which automates imaging analysis.
Teams
Article
Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology
This review focuses on the inherent neurobiology of nigral DAergic neurons and how such neurobiology impacts the primary mechanism of neurotoxicity.
Teams
Article
GEARBOCS: An adeno associated virus tool for in vivo gene editing in astrocytes
GEARBOCS is a non-invasive method for precise gene editing in astrocytes using CRISPR/Cas9. It allows knockout, tagging, and reporter knock-in strategies, revealing the roles of Sparcl1 and Vamp2 in synapse maintenance in the mouse visual cortex.
Teams
Article
Assembloid model to study loop circuits of the human nervous system
Human stem cells are used to create in vitro cortico-striatal-thalamic-cortical circuits, mimicking neural networks involved in neuropsychiatric disorders. This system allows the study of normal development and diseases like autism and Tourette syndrome.
Teams
Article
DIO-SPOTlight transgenic mouse to functionally monitor protein synthesis regulated by the integrated stress response
A new SPOTlight reporter allows visualization of the integrated stress response (ISR) activity in specific cell types in transgenic mice, aiding in studying health and disease implications.
Teams
Article
Reward perseveration is shaped by GABAA-mediated dopamine pauses
Extinction learning is an essential form of cognitive flexibility, which enables obsolete reward associations to be discarded. Here, the team examines the causal relationship of circuit elements to extinction and preservation.
Teams