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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Dataset
Datasets and key resources used in Do, Quyen B. et al. (2023) – Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation
The results highlight the unique utility of modelling striatal neurons in a modular and highly physiological circuit which is essential to reveal mechanistic insights of the loss of electrical functional integrity in the striata of GBA1 PD patients.
Teams
Dataset
SpatialBrain.org – a platform to view integrated data from Wade-Martins Laboratory of Molecular Neurodegeneration
A platform to view integrated data from the Wade-Martins Laboratory of Molecular Neurodegeneration.
Results and data from Kilfeather, Khoo, et al. 2023 (Manuscript in review):
Spatial Transcriptomic Analyses:
-Cell Type Markers
-SN/VTA Markers in Dopaminergic Neurons
-Cell Number Changes in Age
TRAP Analyses:
-Dopaminergic Markers
-Dopaminergic Aging
-Alternative Splicing in Dopaminergic Neurons
Teams
Dataset
Translating ribosome affinity purification analysis of dopaminergic neurons of the mouse ventral midbrain with age and alpha-synuclein overexpression
Comparative gene expression profiling analysis of RNA-seq data for DAT-TRAP samples in 3- and 18-month old mice, with and without human alpha-synuclein overexpression.
Teams
Dataset
Datasets and key resources table from “Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation”
The files found here contain source data, supplementary data, a key resource table, and a list of primers related to the publication “Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation.”
Teams
Dataset
Raw images and quantification of IHC CASR expression from Kilfeather & Khoo et al. (2024) “Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease”
Raw microscopic images and quantification of CASR expression in mouse brain slices.
Teams
Dataset
Raw images and quantification of IHC TYROBP from Kilfeather & Khoo et al. (2024) “Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease”
Raw microscopy images and quantification of TYROBP expression in mouse brain slices.
Teams
Dataset
Stereo-seq raw data of the mouse ventral midbrain with age and alpha-synuclein overexpression
This dataset contains four 3-month old mouse samples and four 18-month old mouse samples. Of each group, the genotype of half samples is wild-type while that of the rests is OVX (human alpha-synuclein overexpression).
Teams
Dataset
Raw immunocytochemistry images and quantification of CASR expression from Kilfeather & Khoo et al. (2024), “Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease”
Raw immunocytochemistry images and quantification of CASR expression in mouse brain slices.
Teams
Dataset
Datasets and key resources table used in Nebuloni, F. et al. (2024) “A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy”
The files found here are associated to Nebuloni, F. et al. (2024) study and contains: (a) all source and supplementary data and (b) key resources table.
Teams
Dataset
Datasets, code, and key resources table from Brimblecombe, K. et al. (2023): “Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson’s”
The following files are associated with Brimblecombe, K. et al. (2023) study: (a) Key Resources Table, (b) all tabular datasets, and (c) Custom R code used to analyze all datasets.
Teams