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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Dataset
Tabular data associated with “Synapsin E-domain is essential for α-synuclein function” (https://doi.org/10.7554/eLife.89687.1)
With previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters. (https://elifesciences.org/reviewed-preprints/89687v1)
Teams
Dataset
Datasets associated with “Peripheral Neuronal Activation Shapes the Microbiome and Alters Gut Physiology”
This RNA data set corresponds to the preprint: Neuronal Activation of the Gastrointestinal Tract Shapes the Gut Environment in Mice (Yoo et al., 2021).
Dataset
Images of adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
CAP-Mac, neuron-biased in infant Old-World primates, is shown to have potential for non-invasive systemic gene transfer in the brains of NHPs.
Teams
Dataset
Fecal metagenomic sequencing data for PD patients and controls from the BioCollective
Fecal metagenomic sequencing data associated with Boktor et al., 2023. This dataset includes samples from the BioCollective cohort.
Dataset
Next-generation sequencing of AAV.CAP-Mac enrichment from Chuapoco et al. (2023)
Dataset of next-generation sequencing of enrichment of AAV.CAP-Mac in various tissues from the publication: Chuapoco, M.R., Flytzanis, N.C., Goeden, N. et al. Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain. Nat. Nanotechnol. (2023). https://doi.org/10.1038/s41565-023-01419-x
Teams
Dataset
Fecal metagenomic sequencing data for PD patients and controls from Rush University Medical Center
Fecal metagenomic sequencing data associated with Boktor et al. (2023). This dataset includes samples from the Rush University Medical Center cohort.
Dataset
Data associated with “Serine-129 phosphorylation of α-synuclein is a trigger for physiologic protein-protein interactions and synaptic function”
The experiments offer a new conceptual platform for investigating the role of Ser129 in synucleinopathies, with implications for drug development.
Teams
Dataset
Data and code for “α-Synuclein Overexpression and the Microbiome Shape the Gut and Brain Metabolome in Mice”
Metabolomic data and analysis code associated with the article, “α-Synuclein Overexpression and the Microbiome Shape the Gut and Brain Metabolome in Mice.”