Catalog
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Crystal structure ATG9 HDIR in complex with the ATG13:ATG101 HORMA dimer
Experimental Data Snapshot
Crystal structure ATG9 HDIR in complex with the ATG13:ATG101 HORMA dimer
PDB DOI: 10.2210/pdb8DO8/pdb
Classification: SIGNALING PROTEIN
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2022-07-12 Released: 2022-11-23
Deposition Author(s): Buffalo, C.Z., Ren, X., Yokom, A.L., Hurley, J.H.
Funding Organization(s): Other private
Method: X-RAY DIFFRACTION
Resolution: 2.41 Å
R-Value Free: 0.251
R-Value Work: 0.204
R-Value Observed: 0.205
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Structure of human ULK1 complex core (2:2:2 stoichiometry) in the PI3KC3-C1 mixture
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-05-04
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
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Structure of human ULK1C:PI3KC3-C1 supercomplex
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-05-05
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
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Structure of human PI3KC3-C1 complex
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-04-29
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
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Structure of human ULK1 complex core (2:1:1 stoichiometry)
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-04-28
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
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Structure of human ULK1 complex core (2:2:2 stoichiometry) of the ATG13(450-517) mutant
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-05-05
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
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Figure S2. pS72 Rab7 formation following depolarization, starvation, and iron chelation [FINAL]
Figure S2. pS72 Rab7 formation following depolarization, starvation, and iron chelation.
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Figure S3: Immunofluorescence of mitochondria alongside LC3B [FINAL]
Figure S3. Immunofluorescence of mitochondria alongside LC3B.
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Figure 1: Rubicon KO starvation and mitophagy HaloTag processing assay
Figure 1. Rubicon depletion promotes bulk autophagy and Parkin mitophagy.
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Raw band intensity values for ATG3 WT or Mutants in vitro LC3 lipidation
Raw band intensity values used for the quantification of in vitro LC3 lipidation results (Fig4C) in Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore.
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Raw band intensity values for Halo-LC3B
Raw band intensity values used for the quantification of percentage autophagy levels.
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Jensen_etal_2022_molecular_dynamics_simulation_data_2
Full molecular dynamics simulation data set accompanying Jensen et al, 2022, containing (i) representative coordinates and measurements described therein, (ii) simulation trajectories, and (iii) GROMACS input files.
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