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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Dataset
Crystal structure ATG9 HDIR in complex with the ATG13:ATG101 HORMA dimer
Experimental Data Snapshot
Crystal structure ATG9 HDIR in complex with the ATG13:ATG101 HORMA dimer
PDB DOI: 10.2210/pdb8DO8/pdb
Classification: SIGNALING PROTEIN
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2022-07-12 Released: 2022-11-23
Deposition Author(s): Buffalo, C.Z., Ren, X., Yokom, A.L., Hurley, J.H.
Funding Organization(s): Other private
Method: X-RAY DIFFRACTION
Resolution: 2.41 Å
R-Value Free: 0.251
R-Value Work: 0.204
R-Value Observed: 0.205
Teams
Themes
Dataset
Structure of human ULK1 complex core (2:2:2 stoichiometry) in the PI3KC3-C1 mixture
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-05-04
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
Teams
Themes
Dataset
Structure of human ULK1C:PI3KC3-C1 supercomplex
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-05-05
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
Teams
Themes
Dataset
Structure of human PI3KC3-C1 complex
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-04-29
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
Teams
Themes
Dataset
Structure of human ULK1 complex core (2:1:1 stoichiometry)
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-04-28
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
Teams
Themes
Dataset
Structure of human ULK1 complex core (2:2:2 stoichiometry) of the ATG13(450-517) mutant
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): No
Deposited: 2023-05-05
Released: 2023-06-21
Deposition Author(s): Chen, M., Hurley, J.H.
Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Michael J. Fox Foundation
Teams
Themes
Dataset
Membrane interaction and mechanism of LC3 lipidation machinery in autophagy – Raw GUV data
Raw GUV data of fluorescent protein imaged on a Nikon A1 confocal microscope with a 63 × Plan 359 Apochromat 1.4 NA objective. Three biological replicates were performed for each experimental 360 condition. Identical laser power and gain settings were used during the course of all conditions.
Teams
Themes
Dataset
RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors
For quantitative results, gray cells represent breaks between independent experiments, or between individual fields of view. Please contact E.L.F. Holzbaur (corresponding author, [email protected]) with any questions or concerns.
Teams
Themes
Dataset
Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore: Molecular dynamics simulation data
Atomistic molecular dynamics simulation data set accompanying manuscript, “Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore.”
Teams
Themes
Dataset
Raw band intensity values for Halo-LC3B
Raw band intensity values used for the quantification of percentage autophagy levels.
Teams
Themes
Dataset
Raw band intensity values for ATG3 WT or Mutants in vitro LC3 lipidation
Raw band intensity values used for the quantification of in vitro LC3 lipidation results (Fig4C) in Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore.
Teams
Themes
Dataset
Unconventional initiation of PINK1/Parkin mitophagy by optineurin
This work reveals that OPTN mitophagy initiation is mechanistically distinct and highlights the mechanistic plasticity of selective autophagy pathways.
Teams
Themes
Dataset
Temporal landscape of mitochondrial proteostasis governed by the UPRmt
This study defines the network of proteostasis mediated by the UPRmt and highlights the value of functional proteomics in decoding stressed proteomes.
Teams
Themes
Dataset
Jensen_etal_2022_molecular_dynamics_simulation_data_2
Full molecular dynamics simulation data set accompanying Jensen et al, 2022, containing (i) representative coordinates and measurements described therein, (ii) simulation trajectories, and (iii) GROMACS input files.
Teams
Themes