Output Catalog

ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.

Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease

Study focuses on mild motor deficits not meeting Parkinson's criteria. Nigrostriatal system changes occur regardless of alpha-synuclein presence, hinting at tau-mediated dopaminergic neurodegeneration initiation. Tau pathology seen in affected groups

Program: Collaborative Research Network

Team: Team Kordower

Alpha-synuclein aggregates are phosphatase resistant

CIAP pretreatment has important implications for the mechanism of PSER129-accumulation in the synucleinopathy brain and provides a simple experimental method to differentiate endogenous from aggregated PSER129.

Program: Collaborative Research Network

Team: Team Kordower

Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy

Parkinson’s disease (PD) involves motor symptoms and αsyn aggregation. GBA1 mutations may worsen PD progression. Testing showed similar αsyn spread regardless of genotype or αsyn strain, with unique interactions found in GBA-PD brains.

Program: Collaborative Research Network

Team: Team Kordower

Rotarod

Rotarod protocol optimized for mice. This test is made to assess motor coordination and balance. The results should show lower latency to fall numbers for mice with motor impairments.

Program: Collaborative Research Network

Team: Team Kordower

Nigrostriatal Tau Pathology in parkinsonism and Parkinson’s disease

While Parkinson’s disease remains clinically defined by cardinal motor symptoms resulting from nigrostriatal degeneration, it is now appreciated that the disease commonly consists of multiple pathologies, but it is unclear where these…

Program: Collaborative Research Network

Team: Team Kordower