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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Article
Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies in Parkinsonism and Parkinson’s Disease
Preprint: Here, the authors look at whether nigrostriatal dopaminergic neurodegeneration occurs independently of alpha-synuclein aggregation for those living with PD. Their findings suggest that it is independent and likely tau mediated.
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Article
Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy
For unclear reasons, PD patients with certain GBA1 mutations (GBA-PD) have a more aggressive clinical progression. The authors tested the two hypotheses for why this occurs; that GBA1 mutations promote αsyn spread or drive the generation of highly pathogenic αsyn polymorphs (i.e., strains).
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Article
Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease
Here, the authors demonstrate that loss of nigral dopaminergic neurons, loss of putamenal dopaminergic innervation, and loss of the tyrosine hydroxylase-phenotype in the substantia nigra and putamen occur equally in mild motor deficit groups with and without nigral alpha-synuclein aggregates.
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Article
Alpha-synuclein aggregates are phosphatase resistant
Phosphorylation of αsyn at serine 129 (PSER129) was considered rare in the healthy human brain but is enriched in pathological αsyn aggregates and is used as a marker for disease inclusions. Recent observations challenge this assumption. The authors investigated conditions under which PSER129 could be detected in the mammalian brain.
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