Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Cellular senescence: a key therapeutic target in aging and diseases
Review: This review discusses the role of SnCs in aging and age-related diseases, strategies to target SnCs, approaches to discover and develop senotherapeutics, and preclinical and clinical advances of senolytics.
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Loss of tau expression attenuates neurodegeneration associated with α-synucleinopathy
Publication: The role of tau in the development of αS pathology and subsequent neuronal dysfunction has been controversial. Herein, the authors examine the role of tau in the onset and progression of αS pathology using a transgenic mouse model of α-synucleinopathy lacking mouse tau expression. View original preprint.
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Adult-onset deletion of ATP13A2 in mice induces progressive nigrostriatal pathway dopaminergic degeneration and lysosomal abnormalities
Publication: The study demonstrates that the adult-onset homozygous deletion of ATP13A2 in the nigrostriatal pathway produces robust and progressive dopaminergic neurodegeneration that serves as a useful in vivo model of ATP13A2-related neurodegenerative diseases. View original preprint.
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Cellular senescence: A key therapeutic target in aging and diseases
This paper discusses cellular senescence as a therapeutic target in aging and age-related diseases, as well as strategies and recent advances in the development of senotherapeutics targeting senescent cells to treat age-related diseases.
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Immune senescence, immunosenescence, and aging
Review: This review focuses on age-related immune dysfunction, cellular senescence and the impaired immune response to pathogens.
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