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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Dataset
Data set of the manuscript “Neuronal hyperactivity-induced oxidant stress promotes in vivo a-synuclein brain spreading”
Data set of the manuscript “Neuronal hyperactivity-induced oxidant stress promotes in vivo a-synuclein brain spreading”.
Teams
Dataset
The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines
The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines. Associated with publication 10.1101/2022.06.01.494130.
Teams
Dataset
Glucocerebrosidase, a Parkinson´s disease-associated protein, is imported into mitochondria and regulates complex I assembly and function
Raw data files used for the manuscript “Glucocerebrosidase, a Parkinson´s disease-associated protein, is imported into mitochondria and regulates complex I assembly and function.” https://www.researchsquare.com/article/rs-1521848/v1
Teams
Dataset
Sex-specific microglial responses to glucocerebrosidase inhibition
Morpho-dynamic analysis occurring in primary cells derived from female and male mice in response to proinflammatory stimulations and glucocerebrosidase inhibition.
Teams
Dataset
Differential response of α-synuclein expression to bacterial ligands and metabolites in mouse enteroendocrine cells
Dataset for manuscript, “α-synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells.” Tabs in excel file are titled with the figure number.
Teams
Dataset
Feacal metagenomic data related to “Evaluation of an Adapted Semi-Automated DNA Extraction for Human Salivary Shotgun Metagenomics”
This study demonstrates that the authors’ semi-automated protocol is suitable for shotgun metagenomic analysis, by significantly producing higher DNA fragment sizes while allowing for improved sample treatment logistics with reduced technical variability and without compromising the structure of the oral microbiome.
Teams
Dataset
Saliva metagenomic data related to “Evaluation of an adapted semi-automated DNA extraction for human salivary shotgun metagenomics”
In this study, the authors proposed a semi-automated DNA extraction protocol for human salivary samples collected with a commercial kit, and compared the outcomes with the DNA extraction recommended by the manufacturer.
Teams
Dataset
LRRK2-G2019S synergizes with aging and low-grade inflammation to promote gut and peripheral immune cell activation that precede nigrostriatal degeneration
Dataset collection related to preprint, “LRRK2-G2019S Synergizes with Aging and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal Degeneration.”
Teams