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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Article
Synchronous measurements of extracellular action potentials and neurochemical activity with carbon fiber electrodes in nonhuman primates
Synchronous measures of spike and dopamine signals displayed contrasting relations to the behavioral task parameters, as taken from the small set of representative data, suggesting a complex relationship between these two modes of neural signaling.
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Article
Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents
The authors’ CFET array has the potential to unlock a wide range of applications, from uncovering the role of neuromodulators in synaptic plasticity, to addressing critical safety barriers in clinical translation towards diagnostic and adaptive treatment in Parkinson’s disease and major mood disorders.
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Article
An open-source MRI-compatible frame for multimodal presurgical mapping in macaque and capuchin monkey
Neurosurgical targeting in nonhuman primates (NHPs) requires presurgical anatomy mapping with neuroimaging techniques (MRI, CT, PET). Given the varied tissue contrasts that these imaging techniques produce, the alignment of imaging-based coordinates to surgical apparatus can be cumbersome. The authors developed an MRI-compatible stereotaxis that allows alignment through technique-specific fiducial markers.
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