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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Dataset
Datasets associated with “Peripheral Neuronal Activation Shapes the Microbiome and Alters Gut Physiology”
This RNA data set corresponds to the preprint: Neuronal Activation of the Gastrointestinal Tract Shapes the Gut Environment in Mice (Yoo et al., 2021).
Dataset
A single-cell atlas of cell types, states, and other transcriptional patterns from nine regions of the adult mouse brain
We report 690K single-cell transcriptomes from nine different brain regions from adult mice (Frontal and Posterior Cortex, Hippocampus, Thalamus, Cerebellum, Striatum, Globus Pallidus externus/Nucleus Basalis, Entopeduncular / Subthalamic Nuclei, & Substantia Nigra / Ventral Tegmental Area).
Teams
Dataset
Subcellular and regional localization of mRNA translation in midbrain dopamine neurons
This dataset is a part of “Subcellular and regional localization of mRNA translation in midbrain dopamine neurons” (Hobson et al., 2022) where the authors investigated mRNA localization in midbrain dopaminergic (mDA) neurons, cells with enormous axonal and dendritic projections, both of which can release dopamine (DA).
Teams
Dataset
ENS quantification
Labelled enteric neurons in living mice with recombinant adeno-associated viruses (rAAVs) expressing fluorescent proteins, and used tissue clearing techniques to enhance visualization of intact GI tissue.
Teams
Dataset
Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures – Fluorospot SFC
Fluorospot SFC (combined IFNg, IL-5, and IL-10) data and corresponding HC-PD group IDs described in “Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures.”
Teams
Dataset
Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures – Gene Validation FCS
FCS files corresponding to the gene validation experiment described in “Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures.”
Teams
Dataset
Fecal metagenomic sequencing data for PD patients and controls from the BioCollective
Fecal metagenomic sequencing data associated with Boktor et al., 2023. This dataset includes samples from the BioCollective cohort.
Dataset
A prebiotic diet modulates microglia response and motor deficits in α-synuclein overexpressing mice (Dataset)
These studies uncover a novel microglia-dependent interaction between diet and motor symptoms in mice, findings that may have implications for neuroinflammation and PD.
Teams
Dataset
Fecal metagenomic sequencing data for PD patients and controls from Rush University Medical Center
Fecal metagenomic sequencing data associated with Boktor et al. (2023). This dataset includes samples from the Rush University Medical Center cohort.
Dataset
Axonal and somatodendritic proteomes of dopamine neurons in the mouse brain
The elaborate cytoarchitecture of DA neurons is embedded within complex brain tissues, making it difficult to access the DA neuronal proteome using conventional methods. This mass spectrometry proteomics dataset is a part of “Subcellular proteomics of dopamine neurons in the mouse brain” (Hobson et al., 2022).
Teams
Dataset
Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures – Cell Surface FCS
FCS files corresponding to the cell surface experiment described in “Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures.”
Teams