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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Article
Membrane potential phase shifts differ for excitation vs. inhibition in resonant pyramidal neurons: a computer modeling study
The authors hypothesize that intrinsic cellular properties complement network properties and contribute to in vivo phase-shift phenomena such as phase precession, seen in place and grid cells, and phase roll, observed in hippocampal CA1 neurons. View original preprint.
Teams
Article
Basal ganglia neurons in healthy and Parkinsonian primates generate recurring sequences of spikes
The authors conclude that basal ganglia neurons fire in recognizable sequences of ISIs, whose incidence is influenced by the induction of parkinsonism.
Teams
Article
Multiscale model of primary motor cortex circuits predicts in vivo cell type-specific, behavioral state-dependent dynamics
Published: The authors developed a biophysically detailed multiscale model of mouse primary motor cortex (M1) with over 10,000 neurons and 30 million synapses. The model accurately predicted in vivo layer- and cell type-specific responses (firing rates and LFP) associated with behavioral states and experimental manipulations (noradrenaline receptor blocking and thalamus inactivation).
Teams
Article
Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism
Preprint: The authors’ data suggest that cell subtype- and synapse-specific adaptations in M1 contribute to altered cortical outputs in parkinsonism and are important aspects of PD pathophysiology.
Teams
Article
Open-source platform for kinematic analysis of mouse forelimb movement
An open-source behavioral platform and software solution for studying fine motor skills in mice performing reach-to-grasp tasks. The behavioral platform uses readily available and 3D-printed components and was designed to be affordable and universally reproducible.
Teams
Article
Dysfunction of motor cortices in Parkinson’s disease
Recent studies in humans with PD and in animal models of the disease have accumulated evidence suggesting that the involvement of the cerebral cortex is complicated. In this review, the authors discuss PD-related changes in frontal cortical motor regions, focusing on neuropathology, changes in neurotransmission, and altered network interactions.
Teams
Article
Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE
Published: The authors built a model of the primary sensory cortex (S1) in NetPyNE, using the data in the Neocortical Microcircuit Collaboration Portal. NetPyNE will make the S1 model more accessible and simpler to scale. View original preprint.
Teams